1
Paul V Goode Jr, James H Brauker, Apurv U Kamath: System and methods for processing analyte sensor data. Dexcom, Knobbe Martens Olson & Bear, August 16, 2005: US06931327 (764 worldwide citation)

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated o ...


2
John F Burd, Peter G Jacobs, William J Sell, Mark C Shults: Systems and methods for remote monitoring and modulation of medical devices. DexCom, Knobbe Martens Olson & Bear, May 6, 2003: US06558321 (764 worldwide citation)

The present invention relates generally to the field of healthcare. Particularly, in the remote monitoring and modulation of a medical device on or in a subject. The present invention provides both systems and methods for remote monitoring of a subject, as well remote treatment of a subject (e.g. mo ...


3
Peter C Simpson, James R Petisce, Victoria Carr Brendel, James H Brauker: Electrode systems for electrochemical sensors. DexCom, Knobbe Martens Olson & Bear, July 11, 2006: US07074307 (728 worldwide citation)

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxi ...


4
James H Brauker, Victoria Carr Brendel, Paul V Neale, Laura A Martinson, Mark A Tapsak: Optimized sensor geometry for an implantable glucose sensor. DexCom, Knobbe Martens Olson & Bear, November 14, 2006: US07134999 (725 worldwide citation)

An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such tha ...


5
Mark C Shults, Stuart J Updike, Rathbun K Rhodes: Device and method for determining analyte levels. DexCom, Knobbe Martens Olson & Bear, May 25, 2004: US06741877 (709 worldwide citation)

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices com ...


6
James H Brauker, Mark C Shults, Mark A Tapsak: Membrane for use with implantable devices. Dexcom, Knobbe Martens Olson & Bear, March 9, 2004: US06702857 (702 worldwide citation)

The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer f ...


7
Paul V Goode Jr, James H Brauker, Apurv U Kamath: System and methods for processing analyte sensor data. DexCom, Knobbe Martens Olson & Bear, October 2, 2007: US07276029 (692 worldwide citation)

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated o ...


8
James H Brauker, Victoria Carr Brendel, Mark A Tapsak: Porous membranes for use with implantable devices. DexCom, Knobbe Martens Olson & Bear, March 20, 2007: US07192450 (648 worldwide citation)

A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular atta ...


9
Peter C Simpson, Paul Goode, Mark A Tapsak, Victoria Carr Brendel: Electrochemical sensors including electrode systems with increased oxygen generation. DexCom, Knobbe Martens Olson & Bear, September 19, 2006: US07108778 (648 worldwide citation)

The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems with at least two electrodes in relatively close proximity to each other; wherein ...


10
Mark C Shults, Stuart J Updike, Rathbun K Rhodes, Barbara J Gilligan, Mark A Tapsak: Device and method for determining analyte levels. DexCom, Knobbe Martens Olson & Bear, March 1, 2005: US06862465 (614 worldwide citation)

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices incl ...