1
Mauro Marina, Viscardi Carlo Felice, Gatti Massimo, Desantis Nicola: Process for the preparation of a dicarboxylic acid dichloride. Fructamine, Mauro Marina, Viscardi Carlo Felice, Gatti Massimo, Desantis Nicola, MINOJA Fabrizio, November 28, 1996: WO/1996/037460 (2 worldwide citation)

The present invention refers to a process for the preparation of S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]-amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride of formula (I) comprising the reaction between S-(-)-[2-(acetyloxy)]propionic acid chloride and 5-amino-2,4,6-triiodo-1,3-benzenedicarbox ...


2
Desantis Nicola: (Fr) Procede de purification dun intermediaire dans la preparation de liopamidol, (En) Process for the purification of an intermediate in the preparation of iopamidol. Fructamine, Desantis Nicola, December 18, 1997: WO/1997/047590 (2 worldwide citation)

(EN) This invention refers to a new process for the synthesis of (S)-N,N'-bis[(2-hydroxy-1-(hydroxy-methyl)ethyl]-5-[(2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzendicarboxamide, of formula (III), starting from 5-amino-2,4,6-triiodo-1,3-benzendicarboxylic acid dichloride characterized by a ne ...


3
Desantis Nicola: A process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid derivatives. Dibra, Desantis Nicola, SPADARO Marco, June 11, 1998: WO/1998/024757 (2 worldwide citation)

The present invention relates to a process for the preparation of non-ionic iodinated contrast media derivatives of 5-amino-1,3-benzenedicarboxylic acid and having a hydroxy-substituted acylamino residue at the 5-position, comprising the following steps without isolating any intermediate: a) reactin ...


4
Desantis Nicola, Incandela Salvatore: (hydroxymethyl) Ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide. Dibra, Desantis Nicola, Incandela Salvatore, MINOJA Fabrizio, November 18, 1999: WO/1999/058494 (2 worldwide citation)

A process for the preparation of S- N,N'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]- 5-[(2- hydroxy-1- oxopropyl)amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide, comprising the formation of S- N,N'- bis[2- hydroxy- 1(hydroxymethyl)ethyl]- 5-[(2- (acetyloxy)- 1-oxopropyl)amino]- 2,4,6- triiodo-1,3- ...


5
Desantis Nicola: (hydroxymethyl)Ethyl]-5-[ (2-hydroxy-1-oxopropyl)amino]-2,4,6- triiodo-1,3-benzendicarboxamide. Bracco International, Desantis Nicola, MINOJA Fabrizio, August 13, 1998: WO/1998/034908

Disclosed is a new process for the crystallisation of (S)-N,N'-bis[2-hydroxy-1- (hydroxymethyl)ethyl]-5-[ (2-hydroxy-1-oxopropyl)amino] -2,4,6-triiodo-1,3-benzendicarboxamide (I), using a linear or branched (C5-C6) alcohol or their mixtures.


6
Desantis Nicola: A process for the preparation of 5-[acetyl (2,3-dihydroxypropyl)amino]-n,n-bis (2,3-dihydroxypropyl)-2,4,6- triiodo-1,3-benzenedicarboxamide. Bracco, Dibra, Desantis Nicola, MINOJA Fabrizio, December 3, 1998: WO/1998/054124

A process for the preparation of 5-[acetyl (2,3-dihydroxypropyl)amino]-N,N'-bis (2,3-dihydroxypropyl)-2,4,6- triiodo-1,3-benzenedicarboxamide of formula (I), starting from 5-amino-1,3-benzenedicarboxylic acid of formula (II), comprising the following steps: step a) is the reaction in heterogeneous p ...


7
Desantis Nicola, Peretto Ilaria, Incandela Salvatore, Viscardi Carlo Felice: A process for the recovery of iodine from aqueous solutions containing iodinated organic compounds. Bracco Imaging, Desantis Nicola, Peretto Ilaria, Incandela Salvatore, Viscardi Carlo Felice, MINOJA Fabrizio, June 8, 2000: WO/2000/032303

A process for the recovery of iodine from mother liquors or wastes containing iodinated organic compounds, by mineralisation of organic iodine and subsequent transformation of the formed iodide into elementary iodine, characterized in that the aqueous solution is concentrated to a suitable volume be ...


8
Desantis Nicola, Incandela Salvatore: A process for the recovery of copper from aqueous solutions containing iodinated organic compounds. Bracco Imaging, Desantis Nicola, Incandela Salvatore, MINOJA Fabrizio, June 21, 2001: WO/2001/044521

The present invention relates to a process for recovering copper from solutions from the recovery of iodine from industrial wastes from the production of ionic and non-ionic iodinated X-ray contrast agents by use of chelating resins suitable for removing copper from aqueous solutions. The absorbed c ...


9
Desantis Nicola, Fedeli Franco: Process for the purification of an aminoalcohol. Dibra, Desantis Nicola, Fedeli Franco, SPADARO Marco, June 11, 1998: WO/1998/024755

The present invention relates to a process for the preparation of 2-amino-1,3-propanediol, having a content of organic impurities lower than 0.1 % and inorganic impurities lower than 0.05 %, comprising the following steps: a) formation of a 2-amino-1,3-propanediol salt with an acid; b) crystallizati ...


10
Desantis Nicola, Peretto Ilaria: (hydroxymethyl) Ethyl]-5- [(2-hydroxy-1- oxopropyl) amino]-2,4,6- triiodo-1,3- benzenedicarboxamide. Bracco Imaging, Desantis Nicola, Peretto Ilaria, MINOJA Fabrizio, March 23, 2000: WO/2000/015602

A process for the preparation of S-N,N'-bis [2-hydroxy-1- (hydroxymethyl) ethyl]-5- [(2-hydroxy-1- oxopropyl) amino]-2,4,6- triiodo-1,3- benzenedicarboxamide, comprising the reaction of S-(-)-5-[[2- (acetyloxy)-1- oxopropyl] amino]-2,4,6-triiodo- 1,3-benzenedicarboxylic acid dichloride (III) with 2- ...