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Yoon Taeyoung, Ge Ping, Delombaert Stephane, Horvath Raymond, Doller Dario, Lu Jingqi, Hodgetts Kevin J, Zhang Lu Yan, John Stanly, Kaiser Bernd, Zhang Xuechun, Shutske Greg, Zhang Cunyu, Darrow Jim, Moorcroft Neil, Yamaguchi Yasuchika: 5-substituted-2-arylpyrazines as modulators of crf receptors. Neurogen Corporation, Aventis Pharmaceuticals, Yoon Taeyoung, Ge Ping, Delombaert Stephane, Horvath Raymond, Doller Dario, Lu Jingqi, Hodgetts Kevin J, Zhang Lu Yan, John Stanly, Kaiser Bernd, Zhang Xuechun, Shutske Greg, Zhang Cunyu, Darrow Jim, Moorcroft Neil, Yamaguchi Yasuchika, ALEXANDER John B, March 4, 2004: WO/2004/018437

Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxiety, depression, ca ...