1
Masakatsu Kaneko, Koji Morita, Takeshi Imanishi: Nucleoside and oligonucleotide analogues. Daiichi Sankyo Company, Mitsubishi Kagaku Foods Corporation, Frishauf Holtz Goodman & Chick P C, January 1, 2008: US07314923 (88 worldwide citation)

A probe for a gene or a primer for starting amplification comprising an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of the nucleoside units is a structure of the formula (2): wherein A represents a C1-C4 alkylene group, and B is an unsubstituted purin-9-yl ...


2
Masakatsu Kaneko, Koji Morita, Takeshi Imanishi: Nucleoside and oligonucleotide analogues. Daiichi Sankyo Company, Mitsubishi Kagaku Foods Corporation, Frishauf Holtz Goodman & Chick P C, February 26, 2008: US07335765 (77 worldwide citation)

A compound of the formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R3)R4, wherein R3 and R4 are the same or different and represent a hydroxyl group, an amino group, an alkoxy group having from 1 to 4 carbon ...


3
Kazuhiko Tamaki, Takahiro Yamaguchi, Kozo Oda, Naoki Terasaka, Daisuke Nakai, Masakazu Nakadai: Benzene compound having 2 or more substituents. Daiichi Sankyo Company, Brandon T Schurter, Locke Lord Bissell & Liddell, April 12, 2011: US07923573 (63 worldwide citation)

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: —COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, opti ...


4
Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu: (Ja) 2以上の置換基を有するベンゼン化合物, (En) Benzene compound having 2 or more substituents. Daiichi Sankyo Company, Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu, YAGUCHI Toshiaki, May 4, 2006: WO/2006/046593 (45 worldwide citation)

(EN) Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, ...


5
MATSUO MASAFUMI, KOIZUMI MAKOTO, TAKESHIMA YASUHIRO: PRODUITS PHARMACEUTIQUES A BASE DACIDE NUCLEIQUE ENA CAPABLES DE MODIFIER LEPISSAGE DE PRECURSEURS DARNM, ENA NUCLEIC ACID PHARMACEUTICALS CAPABLE OF MODIFYING SPLICING OF MRNA PRECURSORS. MATSUO MASAFUMI, TAKESHIMA YASUHIRO, NONPROFIT ORGANIZATION TRANSLATIONAL RESEARCH ORGANIZATION OF DUCHENNE MUSCULAR DYSTROPHY, MATSUO MASAFUMI, TAKESHIMA YASUHIRO, DAIICHI SANKYO COMPANY, ORPHAN DISEASE TREATMENT INSTITUTE, SMART & BIGGAR, April 22, 2014: CA2507125 (31 worldwide citation)

Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578- 2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonuc ...


6
Masafumi Matsuo, Yasuhiro Takeshima, Makoto Koizumi: ENA nucleic acid drugs modifying splicing in mRNA precursor. Masafumi Matsuo, Yasuhiro Takeshima, Daiichi Sankyo Company, Orphan Disease Treatment Institute, Oblon Spivak McClelland Maier & Neustadt L, January 7, 2014: US08624019 (18 worldwide citation)

Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucl ...


7
Hasegawa Masashi, Kimura Youichi, Machinaga Nobuo, Nishinaka Shigeyuki: (Ja) 新規アミドプロピオン酸誘導体およびこれを含有する医薬, (En) Novel amidopropionic acid derivative and pharmaceutical product containing same. Daiichi Sankyo Company, Hasegawa Masashi, Kimura Youichi, Machinaga Nobuo, Nishinaka Shigeyuki, THE PATENT CORPORATE BODY ARUGA PATENT OFFICE, August 16, 2007: WO/2007/091396 (18 worldwide citation)

(EN) Disclosed is a compound having S1P receptor antagonist activity, which is useful as an immunosuppressive agent. The compound has few side effects, and is orally administrable. Specifically disclosed are a compound represented by the general formula (I) below, a salt thereof, a solvate of any of ...


8
Nishi Takahide, Nakamura Tsuyoshi, Sekiguchi Yukiko, Mizuno Yumiko, Shimozato Takaichi, Nara Futoshi: (Ja) ヘテロ環化合物, (En) Heterocyclic compound. Daiichi Sankyo Company, Nishi Takahide, Nakamura Tsuyoshi, Sekiguchi Yukiko, Mizuno Yumiko, Shimozato Takaichi, Nara Futoshi, YAGUCHI Toshiaki, November 2, 2006: WO/2006/115188 (16 worldwide citation)

(EN) Disclosed is a novel low toxic compound having an excellent immunosuppressive action or a pharmacologically acceptable salt thereof. Specifically disclosed is a compound represented by the general formula (I) below, a pharmacologically acceptable salt thereof or a pharmacologically acceptable p ...


9
Hiruma Yoshiharu, Tsuda Eisuke: Antibody targeting osteoclast-related protein siglec-15. Daiichi Sankyo Company, Hiruma Yoshiharu, Tsuda Eisuke, ISHIBASHI Koki, April 16, 2009: WO/2009/048072 (15 worldwide citation)

To provide a method of detecting an abnormality in bone metabolism by using a gene strongly expressing in osteoclasts; a method of screening a compound having an effect of treating and/or preventing an abnormality in bone metabolism; and a medicinal composition for treating and/or preventing an abno ...


10
Koizumi Makoto, Sato Miho: Ena antisense oligonucleotide having sequence-specific action. Daiichi Sankyo Company, Koizumi Makoto, Sato Miho, MAYAMA Setsuko, March 13, 2008: WO/2008/029619 (15 worldwide citation)

It is intended to provide an antisense oligonucleotide that can specifically cleave a target sequence. The antisense oligonucleotide represented by the following sequence (I) or a pharmacologically acceptable salt thereof. Wing1-R11-Window-R12-Wing2 (I) (In the sequence (I), Window represents a deox ...