1
Vos Tricia J, Solomon Michael E, Claiborne Christopher F, Maguire Martin, Dai Mingshi, Patane Michael, Marsilje Thomas H: Melanocortin-4 receptor binding compounds and methods of use thereof. Gene Logic, Vos Tricia J, Solomon Michael E, Claiborne Christopher F, Maguire Martin, Dai Mingshi, Patane Michael, Marsilje Thomas H, HADDAWAY Keith G, December 22, 2005: WO/2005/121100 (22 worldwide citation)

Provided are MC4-R binding compounds of the formula XVII: (XVII), wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss ...


2
Dai Mingshi, Jenkins Tracy J, Guan Bing, Ghosh Shomir, Minor Charles: Ccr8 inhibitors. Millennium Pharmaceuticals, Dai Mingshi, Jenkins Tracy J, Guan Bing, Ghosh Shomir, Minor Charles, DAVIS Steven G, July 15, 2004: WO/2004/058736 (11 worldwide citation)

Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I). Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory ...


3
Guan Bing, Minor Charles, Dai Mingshi, Ghosh Shomir, Jenkins Tracy J, Li Gang, Burdi Douglas F, Bennett Robert A: Ccr8 inhibitors. Millennium Pharmaceuticals, Guan Bing, Minor Charles, Dai Mingshi, Ghosh Shomir, Jenkins Tracy J, Li Gang, Burdi Douglas F, Bennett Robert A, DAVIS Steven G HAMILTON BROOK SMITH HAMILTON BROOK SMITH & REYNOLDS PC 530 Virginia Road PO Box 9133 Concord Massachusetts 01742 9133, July 15, 2004: WO/2004/058709 (10 worldwide citation)

Disclosed are CCR8 inhibitors represented by Structural Formulas (I). The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject ...


4
Maguire Martin P, Dai Mingshi, Vos Tricia J: Melanocortin-4 receptor binding compounds and methods of use thereof. Millennium Pharmaceuticals, Maguire Martin P, Dai Mingshi, Vos Tricia J, HSI Jeffrey D, August 15, 2002: WO/2002/062766 (3 worldwide citation)

MC4-R binding compounds of the formula: B-Z-E (I) wherein B is an anchor moiety, Z is a central moiety, and E is a MC4-R interacting moiety are discussed. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also discussed.


5
Maguire Martin P, Dai Mingshi, Vos Tricia J: Melanocortin-4 receptor binding compounds and methods of use thereof. Millennium Pharmaceuticals, Maguire Martin P, Dai Mingshi, Vos Tricia J, HANLEY Elizabeth A, February 15, 2001: WO/2001/010842

MC4-R binding compounds of the formula (I): B-Z-E wherein B is an anchor moiety, Z is a central moiety, and E is an MC4-R interacting moiety are discussed. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also discussed.