1
Gary W Cleary, Samir Roy: Transdermal drug-delivery composition. Cygnus Research Corporation, Irell & Manella, March 6, 1990: US04906463 (118 worldwide citation)

A solid state, resilient laminated composite for administering a drug transdermally consisting of a multiplicity of spaced structural laminas of a resilient elastomer, one of which forms the top of the composite, a viscoelastic hydrophobic polymer lamina containing propylene glycol monolaurate inter ...


2
Chia Ming Chiang, Gary W Cleary: Skin permeation enhancer compositions. Cygnus Research Corporation, Dianne E Reed, November 27, 1990: US04973468 (98 worldwide citation)

Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, m ...


3
Jesus Miranda, Gary W Cleary: Printed transdermal drug delivery device. Cygnus Research Corporation, Dianne E Reed, April 10, 1990: US04915950 (94 worldwide citation)

A method for making transdermal drug delivery devices is provided which includes: laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive; depositing a drug in liquid form on one face of the source layer; laminating an anchor adhesive layer to the o ...


4
Gary W Cleary: Diffusion matrix for transdermal drug administration and transdermal drug delivery devices including same. Cygnus Research Corporation, Irell & Manella, March 27, 1990: US04911916 (50 worldwide citation)

A solid state, resilient laminated composite for administering a drug transdermally consisting of a top layer of a resilient elastomer; a middle diffusion matrix layer composed of a polyurethane macroporous foam framework in whose pores are embedded a viscoelastic blend of a medical grade polysiloxa ...


5
Colley Kenneth J, Wilson Donald R, Cleary Gary W, Lammintausta Risto, Jalonen Harry: Method and device for administering dexmedetomidine transdermally. Cygnus Research Corporation, Orion Corporation, REED Dianne E, March 7, 1991: WO/1991/002505

Transdermal administration of dexmedetomidine, the dextrorotatory isomer of medetomidine, is described. The method involves sedating a patient by administering dexmedetomidine to a predetermined area of skin at an administration rate and for a time period effective to achieve the desired level of se ...


6
Miranda Jesus, Cleary Gary W: Biphasic transdermal drug delivery device. Cygnus Research Corporation, REED Dianne E, March 7, 1991: WO/1991/002506

A transdermal drug delivery system (10) in which drug delivery is biphasic is provided. Drug is delivered at a therapeutically effective rate during an initial, delivery phase, typically of about 10 to 14 hours, followed by a subsequent, secondary phase during which virtually no drug is delivered. S ...


7
Chiang Chia Ming, Tenzel Renee Ann: Solid matrix system for transdermal drug delivery. Cygnus Research Corporation, REED Dianne E, March 21, 1991: WO/1991/003219

A matrix for containing drugs for transdermal delivery systems is disclosed. The matrix, formed of a skin-adhesive acrylate copolymer, attains high rates of drug delivery without the addition of drug delivery rate enhancers. In preferred embodiments the matrix is used to administer steroids, in part ...


8
Cleary Gary W, Colley Kenneth J, Miranda Jesus, Chiang Chia Ming: Transdermal delivery device having delayed onset. Cygnus Research Corporation, CIOTTI Thomas E, April 4, 1991: WO/1991/003998

A transdermal delivery device has a reservoir containing an active compound, which is kept separate from the delivery layers of the device until administration. At the time of administration, the reservoir is laminated to the delivery layers, or is ruptured to place the active compound, vehicle, and ...


9
Chiang Chia Ming: Transdermal administration of lisuride. Cygnus Research Corporation, CIOTTI Thomas E, January 24, 1991: WO/1991/000746

A laminated composite (10) for administering lisuride transdermally to treat conditions such as Parkinson's disease. The composite comprises an impermeable backing layer (11) and a reservoir layer (12) containing lisuride and a permeation enhancer combined with a pressure-sensitive adhesive with the ...


10
Chiang Chia Ming, Cleary Gary W: Skin permeation enhancer compositions. Cygnus Research Corporation, REED Dianne E, October 4, 1990: WO/1990/011064

Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, m ...