1
Leon WMM Terstappen, Ton Logtenberg: Phage antibodies. Becton Dickinson & Company, Crucell Holland, Irving N Feit, Hoffman & Baron, July 24, 2001: US06265150 (161 worldwide citation)

Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific for subsets of blood leucocytes by flow cytometry. Isolated phage antibodies showed exclusive binding to ...


2
Patrick Hendrikus Cornelis Van Berkel, Abraham Bout, Ton Logtenberg, Ronald Hendrik Pieter Brus: Recombinant production of mixtures of antibodies. Crucell Holland, TraskBritt, August 28, 2007: US07262028 (59 worldwide citation)

The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the ...


3
Van, Berkel Patrick Hendrikus Cornelis, Brus Ronald Hendrik Peter, Bout Abraham, Logtenberg Ton: Recombinant production of mixtures of antibodies. Crucell Holland, Van, Berkel Patrick Hendrikus Cornelis, Brus Ronald Hendrik Peter, Bout Abraham, Logtenberg Ton, KLEIN Bart, January 29, 2004: WO/2004/009618 (46 worldwide citation)

The invention provides methods for producing mixtures of antibodies from a single host cell clone. Thereto a nucleic acid sequence encoding a light chain, and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The antibodies in the mixtures according to ...


4
Ronald Vogels, Menzo Havenga, Majid Mehtali: Complementing cell lines. Crucell Holland, TraskBritt, December 10, 2002: US06492169 (43 worldwide citation)

A packaging cell line capable of complemention recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably human embryonic kidney cells and primary human amniocytes) which are transformed by adenovirus E1 sequences either operatively linked ...


5
Guus Hateboer, Karina Cornelia Verhulst, Govert Johan Schouten, Alphonsus Gerardus Uytdehaag, Abraham Bout: Recombinant protein production in a human cell. Crucell Holland, TraskBritt, February 15, 2005: US06855544 (39 worldwide citation)

Methods and compositions for the production of recombinant proteins in a human cell line. The methods and positions are particularly useful for generating stable expression of human recombinant proteins of interest that are modified post-translationally, for example, by glycosylation. Such proteins ...


6
Fibronectin as a tumor marker detected by phage antibodies. Crucell Holland, July 24, 2002: EP1224943-A1 (36 worldwide citation)

Means and method for at least partial inhibition of tumor growth are provided. Methods makes use of binding molecules capable of specifically binding to an epitope present on a subset of fibronectin proteins. By providing an individual with a binding molecule of the invention it is possible to inter ...


7
Van Den, Brink Edward Norbert, de, Kruif Cornelis Adriaan, Throsby Mark: Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof. Crucell Holland, Van Den, Brink Edward Norbert, de, Kruif Cornelis Adriaan, Throsby Mark, sHATEBOER Guus, March 13, 2008: WO/2008/028946 (35 worldwide citation)

The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising th ...


8
Edward Norbert Van Den Brink, Cornelis Adriaan De Kruif, Mark Throsby: Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof. Crucell Holland, TraskBritt P C, April 8, 2014: US08691223 (33 worldwide citation)

Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying ...


9
Yallop Christopher Adam: Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom. Crucell Holland, Yallop Christopher Adam, KLEIN Bart, November 18, 2004: WO/2004/099396 (30 worldwide citation)

The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6TM cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulti ...


10
Patrick H C Van Berkel, Ronald H P Brus, Ton Logtenberg, Abraham Bout: Recombinant production of mixtures of antibodies. Crucell Holland, TraskBritt, September 30, 2008: US07429486 (26 worldwide citation)

The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the ...



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