1
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Collagen-polymer conjugates. Collagen Corporation, Morrison & Foerster, November 10, 1992: US05162430 (504 worldwide citation)

Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.


2
Woonza M Rhee, Richard A Berg, George H Chu, Frank A DeLustro, Dan M Jolivette, Kimberly A McCullough: Injectable or implantable biomaterials for filling or blocking lumens and voids of the body. Collagen Corporation, Morrison & Foerster, May 19, 1998: US05752974 (490 worldwide citation)

Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistul ...


3
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Collagen-polymer conjugates. Collagen Corporation, Karl Bozicevic, July 12, 1994: US05328955 (305 worldwide citation)

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or ...


4
Donald G Wallace, Hertsel Reihanian, Bruce B Pharriss, William G Braun: Injectable implant composition having improved intrudability. Collagen Corporation, Ciotti & Murashige Irell & Manella, February 7, 1989: US04803075 (298 worldwide citation)

Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.


5
Thomas L Smestad, John McPherson, Donald G Wallace: Injectable cross-linked collagen implant material. Collagen Corporation, Ciotti & Murashige, April 15, 1986: US04582640 (287 worldwide citation)

Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous ...


6
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Biologically inert, biocompatible-polymer conjugates. Collagen Corporation, Karl Bozicevic, June 28, 1994: US05324775 (283 worldwide citation)

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthetic hydrophil ...


7
Donald G Wallace, Susan B Wade: Collagen implant material and method for augmenting soft tissue. Collagen Corporation, Ciotti & Murashige, January 3, 1984: US04424208 (274 worldwide citation)

An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this material have improved persistence relative to curr ...


8
Ranga Nathan, Saied Seyedin, Karl Piez, Hanne Bentz: Inductive collagen based bone repair preparations. Collagen Corporation, Ciotti & Murashige, January 7, 1986: US04563350 (261 worldwide citation)

A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of non-fibrillar collagen. The resulting implants are sufficiently hypo-immunogenic to be effective when implanted in xenog ...


9
George Ksander, Yasushi Ogawa: Collagen wound healing matrices and process for their production. Collagen Corporation, Irella & Manella, August 21, 1990: US04950483 (227 worldwide citation)

Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 t ...


10
Julianne Glowacki, Bruce B Pharriss: Osteogenic composition and method. Collagen Corporation, President and Fellows of Harvard College, Ciotti & Murashige, April 3, 1984: US04440750 (190 worldwide citation)

A plastic dispersion of demineralized bone powder and reconstituted native atelopeptide collagen fibers in a continuous aqueous phase having a substantially physiologic pH and ionic strength is used to repair or construct bone by injecting or implanting it at the repair or construction site. Once em ...