1
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Crosslinked polymer compositions and methods for their use. Cohesion Technologies, Laurie A Axford, Foley & Lardner, April 18, 2000: US06051648 (500 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


2
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Crosslinked polymer compositions and methods for their use. Cohesion Technologies, Fish & Richardson P C, February 23, 1999: US05874500 (345 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


3
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Method of using crosslinked polymer compositions in tissue treatment applications. Cohesion Technologies, Morrison & Foester, December 26, 2000: US06166130 (247 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


4
Donald G Wallace, Gregory M Cruise, Woonza M Rhee, Jacqueline Anne Schroeder, George T Coker III, Marcee M Maroney: Rapid gelling biocompatible polymer composition. Cohesion Technologies, Dianne E Reed, Laurie A Axord, November 6, 2001: US06312725 (217 worldwide citation)

This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, ...


5
Olof Mikael Trollsas, Donald G Wallace, Frank A DeLustro: Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use. Cohesion Technologies, Dianne E Reed, Reed & Associates, October 1, 2002: US06458889 (180 worldwide citation)

Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked biomaterials. The compositions contain at least three biocompatible, nonimmunogenic components having reactive functional groups thereon, with the functional groups selected so ...


6
Donald G Wallace, George H Chu, Jacqueline Anne Schroeder: Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use. Cohesion Technologies, Dianne E Reed, Reed & Associates, December 17, 2002: US06495127 (159 worldwide citation)

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that ...


7
Louis C Sehl, Olof Mikael Trollsas, Donald G Wallace, David Toman, Frank A DeLustro, Jacqueline A Schroeder, George H Chu: Methods for tissue repair using adhesive materials. Cohesion Technologies, Dianne E Reed, Mark L Warzel, Reed Intellectual Property Law Group, December 21, 2004: US06833408 (158 worldwide citation)

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction betwe ...


8
Donald G Wallace, Gregory M Cruise, Woonza M Rhee, Jacqueline Anne Schroeder, George T Coker III, Marcee M Maroney, Olof Mikael Trollsas: Rapid-gelling biocompatible polymer composition and associated methods of preparation and use. Cohesion Technologies, Dianne K Reed, Reed & Eberle, September 23, 2003: US06624245 (118 worldwide citation)

A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i.e., at a selected site within a patient's body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein m≧2 and a biocompatible crosslinking ...


9
David H Sierra: Collagen-polymer matrices with differential biodegradability. Cohesion Technologies, Morrison & Foerster, August 29, 2000: US06110484 (105 worldwide citation)

The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an inter-connecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx ...


10
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Method of making crosslinked polymer matrices in tissue treatment applications. Cohesion Technologies, Laurie A Axford, Dianne E Reed, November 27, 2001: US06323278 (102 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...