1
Stéphane De Lombaert
De, Lombaert Stéphane: Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace. Ciba-Geigy, de, Lombaert Stéphane, January 12, 1995: WO/1995/001353

Disclosed are the tricyclic azepine derivatives of formula (I) wherein X represents oxo, one hydroxy or lower alkoxy and one hydrogen, or two hydrogens; R¿a? and R¿b? independently represent hydrogen, hydroxy, lower alkoxy, nitro, amino or halogen; or R¿a? and R¿b? on adjacent carbons taken together ...


2
Stéphane De Lombaert
De, Lombaert Stéphane: Phosphono substituted tetrazole derivatives. Ciba-Geigy, de, Lombaert Stéphane, sGLYNN Michael W, March 17, 1994: WO/1994/005677

The present invention relates to the N-phosphonomethyl substituted tetrazole derivatives of formula (I) and tautomers thereof wherein R¿0? represents (i) a group of formula (Ia) or (ii) a group of formula -X-COR¿3? (Ib); R and R' represent independently hydrogen, carbocyclic aryl, 6-tetrahydronaphth ...


3
Alain De Mesmaeker, Jacques Lebreton, Adrian Waldner, Phillip D Cook: Backbone modified oligonucleotide analogs. Ciba-Geigy, Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, February 11, 1997: US05602240 (525 worldwide citation)

Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --N ...


4
Karl F Mueller, Eduard K Kleiner: Polysiloxane hydrogels. Ciba Geigy Corporation, Luther A R Hall, January 23, 1979: US04136250 (513 worldwide citation)

A water-insoluble hydrophilic gel comprising (A) about 20 to about 90% by weight of a hydrophilic (a) polymer of identical or different water-soluble monoolefinic monomers, or (b) copolymer of said water-soluble monomers with 1 to 80% (of total monomers) of water-insoluble, identical or different mo ...


5
Ping I Lee: Method of producing annealed polyvinyl alcohol contact lens. Ciba Geigy Corporation, Michael W Glynn, Irving M Fishman, October 28, 1986: US04619793 (408 worldwide citation)

Optically clear soft contact lenses of aqueous swollen solid polyvinyl alcohol having a weight average molecular weight of at least 6,000, having been annealed under crystallinity promoting conditions to effectively increase the elastic modulus of the swollen lenses, and optionally subsequently cros ...


6
Jurg Zimmermann: Pyrimidine derivatives and processes for the preparation thereof. Ciba Geigy Corporation, Karen G Kaiser, May 28, 1996: US05521184 (344 worldwide citation)

There are described N-phenyl-2-pyrimidine-amine derivatives of formula I ##STR1## wherein R.sub.1 is 4-pyrazinyl, 1-methyl-1H-pyrrolyl, amino- or amino-lower alkyl-substituted phenyl wherein the amino group in each case is free, alkylated or acylated, 1H-indolyl or 1H-imidazolyl bonded at a five-mem ...


7
Christian Leumann: Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates. Ciba Geigy Corporation, Kevin T Mansfield, George R Dohmann, June 7, 1994: US05319080 (309 worldwide citation)

Compounds of the formula I in the form of the racemates or enantiomers thereof, ##STR1## in which R.sub.1 and R.sub.2 independently of one another are hydrogen or a protective group, and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for th ...


8
Christian Leumann: Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates. Ciba Geigy Corporation, George R Dohmann, February 28, 1995: US05393878 (302 worldwide citation)

Compounds of the formula I in the form of the racemates or enantiomers thereof, ##STR1## in which R.sub.1 and R.sub.2 independently of one another are hydrogen or a protective group, and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for th ...


9
Phillip D Cook, Gerhard Baschang: Cyclobutyl oligonucleotide surrogates. ISIS Pharmaceuticals, Ciba-Geigy, Woodcock Washburn Kurtz Mackiewicz & Norris, October 25, 1994: US05359044 (260 worldwide citation)

Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.


10
Joseph S Foos, Peter G Edelman, James E Flaherty, Joseph Berger: Electrochemical sensors. Ciba Corning Diagnostics, Ciba-Geigy, Nicholas I Slepchuk Jr, Arthur S Morgenstern, Judith A Roesler, March 28, 1995: US05401376 (252 worldwide citation)

An electrochemical sensor having a substrate, conductive strips deposited on the substrate, and a layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. A solid electrolyte contacting the electrodes is covered by a ...