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Tarran Jones
Masayuki Tsuchiya, Koh Sato, Mary Margaret Bendig, Steven Tarran Jones, Jose William Saldanha: Reshaped human antibody to human interleukin-6 receptor. Chugai Seiyaku Kabushiki Kaisha, Foley & Lardner, January 20, 2009: US07479543 (96 worldwide citation)

A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a momoclonal antibody to the IL-6 receptor ...


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Tadamitsu Kishimoto, Masahiko Mihara, Yoichiro Moriya, Yoshiyuki Ohsugi: Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component. Chugai Seiyaku Kabushiki Kaisha, Tadamitsu Kishimoto, Foley & Lardner, March 30, 1999: US05888510 (113 worldwide citation)

Methods for inhibiting synovial cell growth and treating chronic rheumatoid arthritis are provided. The methods comprise administering a pharmaceutical composition comprising an interleukin-6 antagonist, such as an anti-IL-6 receptor antibody, and a physiologically acceptable carrier.


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Hiroaki Ito, Mitsunari Yamamoto, Tadamitsu Kishimoto: Method of treating inflammatory intestinal diseases containing as the ingredient IL-6 receptors antibodies. Chugai Seiyaku Kabushiki Kaisha, Tadamitsu Kishimoto, Foley & Lardner, April 20, 2004: US06723319 (81 worldwide citation)

A preventive or therapeutic agent for treating bowel disease, including Crohn's disease and ulcerative colitis, where the agent has as an active ingredient an antibody directed against IL-6 receptor which is an interleukin-6 antagonist.


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Osamu Yoshida, Youichi Mizutani: Antitumor agent effect enhancer containing IL-6 antagonist. Chugai Seiyaku Kabushiki Kaisha, Burns Doane Swecker & Mathis L, July 11, 2000: US06086874 (81 worldwide citation)

The present invention discloses an effect enhancer for antitumor agents, examples of which include platinum compounds such as cisplatin and carboplatin, and mitomycin C, that contains interleukin-6 (IL-6) antagonist, examples of which include antibody to IL-6, antibody to IL-6 receptor, and antibody ...


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Katsuhito Miyamoto, Noboru Kubodera, Kiyoshige Ochi, Isao Matsunaga, Eigoro Murayama: vitamin D.sub.3 derivatives having a substituent at 2-position. Chugai Seiyaku Kabushiki Kaisha, Browdy and Neimark, May 19, 1987: US04666634 (80 worldwide citation)

A 1.alpha.-hydroxy vitamin D.sub.3 derivative of the formula: ##STR1## where R.sub.1 is a hydroxyl group, an amino group or the group: OR' (where R' is a lower alkyl group having 1 to 7 carbon atoms that may or may not be substituted by a hydroxyl group, a halogen atom, a cyano group, a lower alkoxy ...


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Toshimasa Tsujinaka, Chikara Ebisui, Junya Fujita: Method for inhibiting muscle protein proteolysis with antibodies to interleukin-6 receptor. Chugai Seiyaku Kabushiki Kaisha, Foley & Lardner, July 17, 2001: US06261560 (75 worldwide citation)

The present invention provides a muscle protein proteolysis inhibiting agent comprising antibody to Interleukin-6 receptor (IL-6R antibody). Antibodies of animals other than humans such as mice and rats, chimeric antibodies of these antibodies with human antibodies, and reshaped human antibodies and ...


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Kawai Shoji: Colorimeter for measuring concentration and indicating the concentration as a digital quantity. Kabushiki Kaisha Kyoto Daiichi Kogaku, Chugai Seiyaku Kabushiki Kaisha, July 3, 1973: US3743429 (66 worldwide citation)

A colorimeter for testing specimens such as blood samples in order to measure the concentration of a material in the specimen and indicate the concentration as a digital quantity. The specimen which is to be tested is supported at a test position, and a signal-producing structure coacts with the spe ...


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Kazushi Shibuya, Masaru Atsumi, Shigeyuki Tsunakawa, Kaneo Nogaki, Thomas Reid Fletcher, Katsuyuki Imada, Bjorn Kenneth Lydersen: Serum-free medium for culturing animal cells. Chugai Seiyaku Kabushiki Kaisha, Irvine Scientific Sales Company, Foley & Lardner, June 18, 2002: US06406909 (64 worldwide citation)

The present invention relates to a serum-free medium for culturing animal cells which contains soybean protein hydrolysate and yeast extract; a method for culturing animal cells which comprises a step of culturing animal cells in the serum-free medium; and a method for producing a desired substance ...