1
William N Drohan, Martin J MacPhee, Shirley I Miekka, Manish S Singh, Clive Elson, John R Taylor Jr: Chitin hydrogels, methods of their production and use. Chitogenics, The American National Red Cross, Coalition for Hemophilia B, Lahive & Cockfield, September 26, 2000: US06124273 (165 worldwide citation)

This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, ...


2
Clive M Elson: N,O-carbonxymethylchitosan for prevention of surgical adhesions. Chitogenics, Lahive & Cockfield, October 21, 1997: US05679658 (25 worldwide citation)

The invention relates to a method of treating patients to minimize post-surgical adhesions and a kit useful in the method of the invention. The method is based on the timing that N,O-carboxymethylchitosan (NOCC) has advantageous properties as a wound healing lavage and coating. A NOCC solution is pa ...


3
Clive M Elson, Agis Kydonieus: Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use. Chitogenics, Ralph A Loren Esq, Palmer & Dodge, October 26, 2004: US06809085 (18 worldwide citation)

The present invention relates to drug delivery devices for moist tissue, in particular mucosal tissue and tissue in the serous cavities, as well as a method of its use. The devices, which contain NOCC, are adherent to the mucosal tissue, allowing localized drug delivery. The devices are particularly ...


4
Clive M Elson: Covalently linked N,O-carboxymethylchitosan and uses thereof. Chitogenics, Lahive & Cockfield, March 30, 1999: US05888988 (13 worldwide citation)

Covalent compositions of N,O-carboxymethyl chitosan (NOCC) are disclosed. NOCC can be intra- or intermolecularly linked, either through a direct bond or through a bridging moiety. Also disclosed are methods for preparing and using the covalent NOCC compositions. The NOCC compositions are useful in t ...


5
Agis Kydonieus, Clive Elson, Maya Thanou: Methods of drug delivery using sulphated chitinous polymers. Chitogenics, Ralph Loren, Edwards Angell Palmer and Dodge, September 4, 2007: US07265097 (5 worldwide citation)

The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes a sulphated chitinous polymer as ...


6
Susan Elizabeth Henderson, Dennis Thomas Curran, Clive M Elson: Negatively charged chitosan derivative semiochemical delivery system. Chitogenics, Lahive & Cockfield, July 8, 1997: US05645844 (5 worldwide citation)

The present invention features a method and composition for attracting a target insect to a selected location. The invention is based on the discovery that negatively charged chitosan polymers, e.g., NOCC, have advantageous properties for use in a semiochemical delivery system for releasing a volati ...


7
Clive Elson, Timothy D G Lee: Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins. Chitogenics, Ralph A Loren Esq, Edwards Angell Palmer & Dodge, July 3, 2007: US07238678 (2 worldwide citation)

The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are prevented or greatly reduced.


8
Clive M Elson, Timothy D G Lee: Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins. Chitogenics, Ralph A Loren Esq, Lahive & Cockfield, November 11, 2003: US06645947 (2 worldwide citation)

The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are prevented or greatly reduced.


9
Clive Elson, Timothy D G Lee: Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins. Chitogenics, Ralph A Loren, Palmer & Dodge, May 17, 2005: US06894035 (1 worldwide citation)

The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are prevented or greatly reduced.


10
Kydonieus Agis, Elson Clive, Thanou Maya: Methods of drug delivery using sulphated chitinous polymers. Chitogenics, Universiteit Leiden, Kydonieus Agis, Elson Clive, Thanou Maya, LOREN Ralph A, March 4, 2004: WO/2004/018010 (1 worldwide citation)

The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes a sulphated chitinous polymer as ...