1
Robert McCaffrey, Katarina Tkacik, Brian Holman, James Flaherty, Josef Brown, Peter Edelman: Sensors for measuring analyte concentrations and methods of making same. Chiron Diagnostics Corporation, Arthur S Morgenstern, Stanley Sacks, Robert P Blackburn, January 13, 1998: US05707502 (397 worldwide citation)

A sensor for measuring a concentration of an analyte in a solution. The sensor comprises a substrate layer, an electrode layer and an immobilized enzyme layer. The sensor further includes an enzyme/polymer layer and/or a hydrophobic layer. The enzyme/polymer layer includes an enzyme disposed within ...


2
Paul A D Orazio, David Sogin: Three-layered membrane for use in an electrochemical sensor system. Chiron Diagnostics Corporation, Arthur S Morgenstern, Gerry A Blodgett, Robert P Blackburn, June 30, 1998: US05773270 (224 worldwide citation)

A system for electrochemical measurement of glucose concentration in an undiluted test sample, e.g. blood is provided containing a sensor including a three-layered contiguous membrane. The membrane has a thickness of 50 to 130 microns, and is composed of a 1 to 10 micron thick first layer, a 10 to 3 ...


3
Thomas C Maley, Mark W Boden, Paul A D Orazio, Peter G Edelman: Glucose and lactate sensors. Chiron Diagnostics Corporation, Arthur S Morgenstern, Stanley Sacks, Robert P Blackburn, June 23, 1998: US05770028 (214 worldwide citation)

A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion ...


4
Robert McCaffrey, Bonnie Dalzell, Katarina Tkacik, Susan Holbert, Mark Boden, James Flaherty, Michael Flanagan, Josef Brown, Kimiya Takeshita, Peter Edelman: Multilayer enzyme electrode membranes and methods of making same. Chiron Diagnostics Corporation, Arthur S Morgenstern, Stanley Sacks, Robert P Blackburn, December 9, 1997: US05696314 (170 worldwide citation)

An electrochemical sensor is designed for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by provid ...


5
Allison L Abel, Paul A D Orazio, Bonnie C Dalzell, Robert R McCaffrey, Laura S Uretsky: Reagents with enhanced performance in clinical diagnostic systems. Chiron Diagnostics Corporation, Arthur S Morgenstern, Stanley Sacks, Robert P Blackburn, September 16, 1997: US05667983 (137 worldwide citation)

It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one or (2) 5-bromo-5-nitro-1,3-dioxane, that are used in clinical diagnostic reagents. It has a ...


6
Thomas C Maley, Paul A D Orazio, Peter G Edelman, John A Zalenski: Electrochemical sensors paste. Chiron Diagnostics Corporation, Judith A Roesler, Stanley Sacks, Robert Blackburn, April 1, 1997: US05616222 (132 worldwide citation)

A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion ...


7
David J Lapeus, Michael Ballash: Magnetic conveyor system. Chiron Diagnostics Corporation, Arthur S Morgenstern, Charles Gagnebin III, Robert P Blackburn, February 24, 1998: US05720377 (94 worldwide citation)

A magnetic conveyor system for transporting test samples in tubes disposed in a sample rack having a magnetic or magnetically attractive region is described. The magnetic conveyor system includes a drive system, a magnet coupled to the drive system and movable in response to the drive system and a t ...


8
Glen A Carey, Scott C Lewis, Raymond A Mann, Mary B Whitesel, James P Polaniec, George J Woyansky, Stefan R Pabst, Frank C Klingshirn: Automated analyzer with reagent agitating device. Chiron Diagnostics Corporation, Wilfred F DesRosiers, Judith A Roesler, Robert P Blackburn, June 10, 1997: US05637275 (88 worldwide citation)

An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent ...


9
James P Polaniec, David J Lapeus, Mary Beth Whitesel: Specimen rack handling system. Chiron Diagnostics Corporation, Arthur S Morgenstern, Charles L Gagnebin III, Robert P Blackburn, April 7, 1998: US05735387 (86 worldwide citation)

A magnetic conveyor system for transporting test samples in tubes disposed in a sample rack having a magnetic or magnetically attractive region is described. The magnetic conveyor system includes a drive system, a magnet coupled to the drive system and movable in response to the drive system and a t ...


10
Glen A Carey, Scott C Lewis, Mary Beth Whitesel, George J Woyansky, Stefan R Pabst, Frank C Klingshirn: Luminometer for an automated analyzer. Chiron Diagnostics Corporation, Wilfred F DesRosiers, Judith A Roesler, Robert P Blackburn, August 5, 1997: US05653940 (82 worldwide citation)

An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent ...