1
James E Lock, Carol A Ryan, Clifford J Dwyer: Self-centering umbrella-type septal closure device. Children s Medical Center Corporation, Testa Hurwitz & Thibeault, January 20, 1998: US05709707 (309 worldwide citation)

A self-centering umbrella-type septal closure device which includes a proximal and distal occluder each having a plurality of arms supporting the occlusion shells. Each of the proximal and distal support arms have at least three coils any one or more of which is secured by a centering mechanism so a ...


2
Robert Langer, Robert J Levy: Biomaterial implants which resist calcification. Children s Medical Center Corporation, June 28, 1988: US04753652 (280 worldwide citation)

A biomaterial implant into which is incorporated a sustained release polymer containing an anticalcium agent.


3
Rahul Singhvi, Amit Kumar, George M Whitesides, Donald E Ingber, Gabriel P Lopez, Daniel I C Wang, Gregory N Stephanopoulos: Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor. President and Fellows of Harvard College, Massachusetts Institute of Technology, Children s Medical Center Corporation, Wolf Greenfield & Sacks P C, July 7, 1998: US05776748 (237 worldwide citation)

The disclosed invention is a device for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere cells which are isolated by cytophobic regions to which cells do not adhere and further is contiguous wit ...


4
John K Triedman, Kathy J Jenkins, Steven D Colan: Method for endocardial activation mapping using a multi-electrode catheter. Children s Medical Center Corporation, Thomas J Engellenner, Lawrence E Lahive & Cockfield Monks, December 15, 1998: US05848972 (230 worldwide citation)

A system and method is disclosed to improve the ability of physicians, researchers and others to digest large amounts of cardiac electrophysiologic data acquired during cardiac catheterization, improving their ability to visualize, interpret and act on its content. The technique addresses previous l ...


5
Anthony Atala, Samy Ashkar: Injectable non-immunogenic cartilage and bone preparation. Children s Medical Center Corporation, Arnall Golden & Gregory, May 14, 1996: US05516532 (228 worldwide citation)

Ground bone or cartilage particles are demineralized by extraction with a low ionic strength buffer such as 20 mM HEPES containing a chelating agent and protease inhibitors, then extracted with an acidic solution such as 0.3M citric acid, pH 4.0, containing protease inhibitors. The extracted materia ...


6
Anthony Atala: Retractable suture needle with self-contained driver. Children s Medical Center Corporation, Thomas J Lahive & Cockfield Engellenner, November 5, 1996: US05571119 (217 worldwide citation)

Methods and apparatus for suturing in physically confined and visually restricted areas are disclosed. Suturing instruments are described that serve to deliver suture material through biological tissue by extending and retracting the distal portion of the instrument through the tissue. Suture needle ...


7
James E Lock, Valerie Mandell, Stanton Perry: Re-expandable endoprosthesis. Children s Medical Center Corporation, Kohn & Associates, January 7, 1997: US05591223 (203 worldwide citation)

A radially expandable endoprosthesis device (10) comprises an elongated sleeve member (12) in which the radially outward expansion of the sleeve member (12) is initially limited by connecting strips (22) which are operatively connected to the sleeve member (12). The connecting strips (22) are select ...


8
Antonios G Mikos, Georgios Sarakinos, Joseph P Vacanti, Robert S Langer, Linda G Cima: Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures. Massachusetts Institute of Technology, Children s Medical Center Corporation, Arnall Golden & Gregory, May 7, 1996: US05514378 (203 worldwide citation)

Biocompatible porous polymer membranes are prepared by dispersing salt particles in a biocompatible polymer solution. The solvent in which the polymer is dissolved is evaporated to produce a polymer/salt composite membrane. The polymer can then be heated and cooled at a predetermined constant rate t ...


9
Anthony Atala, James Mandell: Directly visualized method for deploying a detachable balloon at a target site in vivo. Children s Medical Center Corporation, Thomas J Engellenner, Elizabeth A Lahive & Cockfield Hanley, May 2, 1995: US05411475 (199 worldwide citation)

A directly visualized method for deploying a detachable balloon to a target site in vivo is described. The method allows a physician or technician to deploy the detachable balloon to the target site while directly visualizing the detachment of the balloon and/or the effects of the detached balloon o ...


10
Joseph P Vacanti, Robert S Langer: Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo. Massachusetts Institute of Technology Children s Medical Center Corporation, Arnall Golden & Gregory, June 23, 1998: US05770417 (171 worldwide citation)

A cell-scaffold composition is prepared in vitro for implanting to produce functional organ tissue in vivo. The scaffold is three-dimensional and is composed of hollow or solid fibers of a biocompatible, synthetic polymer which is biodegradable or non-biodegradable. The fibers of the scaffold may ha ...