1
Leland Clark Jr: Implantable gas-containing biosensor and method for measuring an analyte such as glucose. Children s Hospital Medical Center, Wood Herron & Evans, July 14, 1987: US04680268 (547 worldwide citation)

The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an encl ...


2
Leland C Clark Jr: Implantable gas-containing biosensor and method for measuring an analyte such as glucose. Children s Hospital Medical Center, Wood Herron & Evans, January 26, 1988: US04721677 (543 worldwide citation)

The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an encl ...


3
Leland C Clark Jr: Cutaneous methods of measuring body substances. Children s Hospital Medical Center, Wood Herron & Evans, August 30, 1983: US04401122 (333 worldwide citation)

Cutaneous methods for measurement of substrates in mammalian subjects are disclosed. A condition of the skin is used to measure a number of important substances which diffuse through the skin or are present underneath the skin in the blood or tissue. According to the technique, an enzyme whose activ ...


4
Leland C Clark Jr: Cutaneous methods of measuring body substances. Children s Hospital Medical Center, Wood Herron & Evans, July 10, 1984: US04458686 (289 worldwide citation)

Cutaneous methods for measurement of substrates in mammalian subjects are disclosed. A condition of the skin is used to measure a number of important substances which diffuse through the skin or are present underneath the skin in the blood or tissue. According to the technique, an enzyme whose activ ...


5
Leland C Clark Jr: Polarographic analysis of cholesterol and other macromolecular substances. Children s Hospital Medical Center, Wood Herron & Evans, August 9, 1977: US04040908 (271 worldwide citation)

A micro-method for measurement of sterols such as cholesterol, and other macromolecular substances, is disclosed utilizing enzymes for the conversion of such substances to produce ultimately hydrogen peroxide and measurement of the generated hydrogen peroxide with a membrane covered polarographic an ...


6
Roger I Hardy: Method and apparatus for transmyocardial revascularization using a laser. Children s Hospital Medical Center, Wood Herron & Evans, April 21, 1987: US04658817 (240 worldwide citation)

A surgical carbon dioxide laser is disclosed which includes a handpiece for directing a laser beam to a desired location. Mounted on the forward end of the handpiece is a hollow needle precisely aligned along the laser path. This permits the laser to be used in surgical applications where the needle ...


7
Leland Clark Jr: Polarographic method for measuring both analyte and oxygen with the same detecting electrode of an electroenzymatic sensor. Children s Hospital Medical Center, Wood Herron & Evans, July 9, 1991: US05030333 (222 worldwide citation)

Novel polarographic (voltametric) methods for measuring in vivo or in vitro analytes in an animal tissue and oxygen in the sensor enzymatic reaction layer with an electroenzymatic sensor are disclosed. The new and vastly improved methods are directed to generating from the electroenzymatic sensor at ...


8
Leland C Clark Jr: Method of polarographic analysis of lactic acid and lactate. Children s Hospital Medical Center, Wood Herron & Evans, August 28, 1984: US04467811 (166 worldwide citation)

A method of measuring lactic acid or lactate and derivatives thereof in liquids which is extremely versatile and is suitable for use in a number of areas such as the rapid measurement of lactic acid in whole blood, the ratio of lactic acid to pyruvic acid in whole blood, in-vivo measurement of lacti ...


9
Yuli Kitaevich, Nat Hemasilpin, J Gabriel Marchevsky, John J Bissler, George Benzing III, Paul T McEnery: Hemofiltration system and method. Children s Hospital Medical Center, Wood Herron & Evans, May 18, 1993: US05211849 (123 worldwide citation)

A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoi ...


10
Moses J Folkman, Robert S Langer Jr: Systems for the controlled release of macromolecules. The Children s Hospital Medical Center, July 5, 1983: US04391797 (110 worldwide citation)

Delivery systems manufactured in the form of polymeric compositions for the controlled delivery of macromolecules to environments of use are disclosed. The systems are characterized as two-phase compositions comprising a phase formed of an insoluble polymeric matrix having limited water sorptivity c ...