1
Vo Nha Huu, Chen Shoujun, Che Qinglin, Xie Yu: Thiazole and thiadiazole compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Vo Nha Huu, Chen Shoujun, Che Qinglin, Xie Yu, HSI Jeffrey D, August 2, 2007: WO/2007/087427 (52 worldwide citation)

The invention relates to compounds of structural formula (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R'i, X, X', L and Y are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, ...


2
Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


3
Chen Shoujun, Sun Lijun, Xie Yu: Benzimidazolyl-pyridine compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Chen Shoujun, Sun Lijun, Xie Yu, HSI Jeffrey D, October 4, 2007: WO/2007/112093 (38 worldwide citation)

The invention relates to compounds of formula (XVI): (XVI) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein Y2, Z, L1, R9, R10, m and u are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditi ...


4
Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori, DAVIS Steven G, August 5, 2004: WO/2004/064826 (37 worldwide citation)

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...


5
Xie Yu, Holmqvist Mats, Mahiou Jerome, Ono Mitsunori, Sun Lijun, Chen Shoujun, Zhang Shijie, Jiang Jun, Chimmanamada Dinesh, Fleig Andrea, Yu Chih Yi: Method for modulating calcium ion-release-activated calcium ion channels. Synta Pharmaceuticals, Xie Yu, Holmqvist Mats, Mahiou Jerome, Ono Mitsunori, Sun Lijun, Chen Shoujun, Zhang Shijie, Jiang Jun, Chimmanamada Dinesh, Fleig Andrea, Yu Chih Yi, HSI Jeffrey D, February 3, 2005: WO/2005/009954 (28 worldwide citation)

The invention relates to a method for modulating Ca 2'-release-activated Ca 2+ channels (CRAG) in a cell by administering to the cell a compound of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein.


6
Jiang Jun, Zhang Junyi, Vo Nha Huu, Chen Shoujun: Phenyl and pyridyl compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Jiang Jun, Zhang Junyi, Vo Nha Huu, Chen Shoujun, HSI Jeffrey D, August 2, 2007: WO/2007/087429 (28 worldwide citation)

The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R1, X1, X2, Y, Z, L, and n are defined herein. The compounds are useful as immunosuppressive agents and for treating and preventing inflammatory condit ...


7
Sun Lijun, Chen Shoujun, Jiang Jun, Xie Yu, Yu Chih Yi: Compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Sun Lijun, Chen Shoujun, Jiang Jun, Xie Yu, Yu Chih Yi, HSI Jeffrey D, August 3, 2006: WO/2006/081391 (27 worldwide citation)

The invention relates to compounds of structural formula (I) and structural formula (Vl): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R, R1, R2, Z, L, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and prev ...


8
Sun Lijun, Chen Shoujun, Jiang Jun, Xia Zhi Qiang, Xie Yu, Yu Chih Yi: Thiophene compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Sun Lijun, Chen Shoujun, Jiang Jun, Xia Zhi Qiang, Xie Yu, Yu Chih Yi, HSI Jeffrey D, August 3, 2006: WO/2006/081389 (23 worldwide citation)

The invention relates to compounds of structural formulas (I) and (XVI) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, Z, L, L2, R1, R2, R3, R21, n, q, and t are defined herein. These compounds are useful as immunosuppressive agents and for treating an ...


9
Sun Lijun, Chen Shoujun, Xia Zhi Qiang, Jiang Jun, Xie Yu, Zhang Junyi: Compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Sun Lijun, Chen Shoujun, Xia Zhi Qiang, Jiang Jun, Xie Yu, Zhang Junyi, HSI Jeffrey D, August 10, 2006: WO/2006/083477 (23 worldwide citation)

The invention relates to compounds of structural formulas (I), (VII) and (Xl): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein XI, X2, X3. Y, Z, L, R1, R2, R3, R18 and n are defined herein. These compounds are useful as immunosuppressive agents and for treating ...


10
Chen Shoujun, Koya Keizo, Demko Zachary, Sun Lijun: Compounds for treating proliferative disorders. Synta Pharmaceuticals, Chen Shoujun, Koya Keizo, Demko Zachary, Sun Lijun, DAVIS Steven G, February 28, 2008: WO/2008/024303 (21 worldwide citation)

Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variabables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disord ...