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Stevens Sean, Huang Tammy T, Martin Joel H, Fairhurst Jeanette L, Rafique Ashique, Smith Eric, Pobursky Kevin J, Papadopoulos Nicholas J, Fandl James P, Chen Gang, Karow Margaret: High affinity antibodies to human il-6 receptor. Regeneron Pharmaceuticals, Stevens Sean, Huang Tammy T, Martin Joel H, Fairhurst Jeanette L, Rafique Ashique, Smith Eric, Pobursky Kevin J, Papadopoulos Nicholas J, Fandl James P, Chen Gang, Karow Margaret, GREGG Valeta, December 13, 2007: WO/2007/143168 (40 worldwide citation)

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hlL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. The antibody or antibody fragment binds hlL-6R with an affinity at least 2-fold higher relative to its binding to monkey ...


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Fandl James, Chen Gang, Papadopoulos Nicholas, Aldrich Thomas H: Fusion polypeptides capable of activating receptors. Regeneron Pharmaceuticals, Fandl James, Chen Gang, Papadopoulos Nicholas, Aldrich Thomas H, GREGG Valeta, August 4, 2005: WO/2005/070966 (17 worldwide citation)

A fusion polypeptide comprising (A)x-M-(A’)Y, wherein A and A’ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A’ may be each be an antibody or fragment derived form an antibody sp ...


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Masat Linda, Haak Frendscho Mary, Chen Gang, Horwitz Arnold, Roell Marina: Il-1&bgr; binding antibodies and fragments thereof. Xoma Technology, Masat Linda, Haak Frendscho Mary, Chen Gang, Horwitz Arnold, Roell Marina, HARLIN Michael B, January 4, 2007: WO/2007/002261 (12 worldwide citation)

An IL- 1&bgr; binding antibody or IL- 1&bgr; binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL- 1&bg ...


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Chen Gang: Air cushion. Chen Gang, October 22, 2003: CN02108942 (11 worldwide citation)

The present invention relates to an air cushion. Said air cushion is formed from two or more than two air cushion units which are transversely or longitudinally connected together, and several small air-charged bags are filled into the hollow of rectangular body which is made of fabric and whose two ...


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Ren Zhifeng, Poudel Bed, Chen Gang, Lan Yucheng, Wang Dezhi, Hao Qing, Dresselhaus Mildred, Ma Yi, Yan Xiao, Chen Xiaoyuan, Wang Xiaowei, Joshi Giri Raj, Yu Bo: Methods for high figure-of-merit in nanostructured thermoelectric materials. Massachusetts Institute of Technology, Ren Zhifeng, Poudel Bed, Chen Gang, Lan Yucheng, Wang Dezhi, Hao Qing, Dresselhaus Mildred, Ma Yi, Yan Xiao, Chen Xiaoyuan, Wang Xiaowei, Joshi Giri Raj, Yu Bo, MOLLAAGHABABA Reza, November 20, 2008: WO/2008/140596 (6 worldwide citation)

Thermoelectric materials with high figures of merit, ZT values, are disclosed In many instances, such materials include nano-sized domains (e g, nanocrystalhne), which are hypothesized to help increase the ZT value of the material (e g, by increasing phonon scattering due to interfaces at grain boun ...


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Bridger Gary J, Mceachern Ernest J, Skerlj Renato, Schols Dominique, Baird Ian, Kaller Al, Harwig Curtis, Zhu Yongbao, Chen Gang, Skupinska Krystyna: Cxcr4 chemokine receptor binding compounds. Anormed, Bridger Gary J, Mceachern Ernest J, Skerlj Renato, Schols Dominique, Baird Ian, Kaller Al, Harwig Curtis, Zhu Yongbao, Chen Gang, Skupinska Krystyna, TONGCO Emily C, October 28, 2004: WO/2004/091518 (5 worldwide citation)

The present invention relates to compounds that bind to chemokine receptors, and having the formula (I) wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as r ...