1
D Lansing Taylor: Miniaturized cell array methods and apparatus for cell-based screening. Cellomics, David S Harper, McDonnell Boehnen Hulbert & Berghoff, August 15, 2000: US06103479 (228 worldwide citation)

The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellular and subcellular level as well as temporal ...


2
R Terry Dunlay, D Lansing Taylor: System for cell-based screening. Cellomics, David S McDonnell Boehnen Hulbert & Berghoff Harper, November 23, 1999: US05989835 (222 worldwide citation)

The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluor ...


3
Ravi Kapur, Terri Adams: Miniaturized cell array methods and apparatus for cell-based screening. Cellomics, David S Harper, McDonnell Boehnen Hulbert & Berghoff, April 15, 2003: US06548263 (112 worldwide citation)

The present invention describes novel methods for making a substrate for selective cell patterning, and the substrates themselves, wherein the method comprises contacting reactive hydroxyl groups on the surface of a substrate with a hydroxyl-reactive bifunctional molecule to form a monolayer, and us ...


4
R Terry Dunlay, D Lansing Taylor, Albert H Gough, Kenneth A Giuliano: System for cell-based screening. Cellomics, McDonnell Boehnen Hulbert & Berghoff, April 27, 2004: US06727071 (84 worldwide citation)

The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specificall ...


5
R Terry Dunlay, D Lansing Taylor: System for cell-based screening. Cellomics, David S Harper, McDonnell Boehnen Hulbert & Berghoff, September 16, 2003: US06620591 (79 worldwide citation)

The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluor ...


6
Paul Sammak, Thomas D Duensing, Richard A Rubin: System for cell-based screening. Cellomics, McDonnell Boehnen Hulbert & Berghoff, April 6, 2004: US06716588 (76 worldwide citation)

The present invention provides automated systems, methods, screens, and software for the analysis of cell spreading. The invention involves providing cells containing fluorescent reporter molecules in an array of locations, contacting the cells with a test stimulus, acquiring images from the cells, ...


7
Ricardo L Colasanti, Mark A D Collins, John R Shaw: Method and system for interpreting and validating experimental data with automated reasoning. Cellomics, McDonnell Boehnen Hulbert & Berghoff, November 2, 2004: US06813615 (70 worldwide citation)

A method and system for interpreting experimental data with automated reasoning. Domain specific knowledge is acquired from one or more pharmaceutical information sources. A semantic representation of the domain specific knowledge is created meeting a desired set of criteria. Pharmaceutical data fro ...


8
Ravi Kapur, Kenneth Giuliano: Miniaturized cell array methods and apparatus for cell-based screening. Cellomics, McDonnell Boehnen Hulbert & Berghoff, January 9, 2007: US07160687 (68 worldwide citation)

The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a doma ...


9
R Terry Dunlay, D Lansing Taylor, Albert H Gough, Kenneth A Giuliano: Machine readable storage media for detecting distribution of macromolecules between nucleus and cytoplasm in cells. Cellomics, David S Harper, McDonnell Boehnen Hulbert & Berghoff, December 30, 2003: US06671624 (58 worldwide citation)

The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specificall ...


10
Richard A Rubin, Kenneth A Giuliano, Albert H Gough, R Terry Dunlay: System for cell-based screening. Cellomics, McDonnell Boehnen Hulbert & Berghoff, July 6, 2004: US06759206 (44 worldwide citation)

The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent labeling of the receptor of interest and the automated measurement of receptor internalization to a perinuc ...