1
Robert J Sweeney, Bruce H KenKnight: Cardiac rhythm management system with arrhythmia prediction and prevention. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, August 7, 2001: US06272377 (446 worldwide citation)

A cardiac rhythm management system predicts when an arrhythmia will occur and in one embodiment invokes a therapy to prevent or reduce the consequences of the arrhythmia. A cardiac arrhythmia trigger/marker is detected from a patient, and based on the trigger/marker, the system estimates a probabili ...


2
James E Leslie, Everett D Anderson: Ambulatory infusion pump having programmable parameters. Cardiac Pacemakers, Orrin M Haugen, Thomas J Nikolai, Douglas L Tschida, July 16, 1985: US04529401 (428 worldwide citation)

A portable infusion pump for controllably supplying a programmed volume of medicant to a patient. The apparatus generally comprises a small, portable container having a keyboard for programming the mode of operation and operating parameters, whereby a microprocessor controls the pump in the various ...


3
Jesse W Hartley, Marc H Cohen, Nicholas J Stessman, Scott A Reedstrom, Steven D Check, James P Nelson: Rate adaptive cardiac rhythm management device using transthoracic impedance. Cardiac Pacemakers, Schwegman Lundberg Woessner and Kluth, June 13, 2000: US06076015 (370 worldwide citation)

A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A tra ...


4
Roger W Dahl, Robert W Wickham deceased, David K Swanson, David Lipson: Stent-type defibrillation electrode structures. Cardiac Pacemakers, Haugen and Nikolai, July 2, 1996: US05531779 (337 worldwide citation)

Implantable electrode structures for use in apparatus for applying electrical therapy to a patient's heart in the treatment of arrhythmias such as tachycardias and fibrillations of the heart are herein disclosed. The electrode structures are made in the form of expandable (or self-expanding) intrava ...


5
Weimin Sun, Thomas M Castellano, Russ E Anderson, Wade A Bowe, John A Simpson, Marshall L Sherman, Kathryn E Lockwood: RF ablation apparatus and method having electrode/tissue contact assessment scheme and electrocardiogram filtering. Cardiac Pacemakers, Fulwider Patton Lee & Utecht, May 21, 2002: US06391024 (329 worldwide citation)

A method of assessing the adequacy of contact between an ablation electrode and biological tissue within a biological organ having biological fluid therein includes the steps of positioning the ablation electrode proximal the biological tissue; positioning a reference electrode a distance from the a ...


6
Gerrard M Carlson, Veerichetty A Kadhiresan, Julio C Spinelli: Heart rate variability as an indicator of exercise capacity. Cardiac Pacemakers, Nikolai Merserau & Dietz P A, February 15, 2000: US06026320 (317 worldwide citation)

Based upon patient studies indices a high degree of correlation was found between HRV and VO2.sub.max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient' ...


7
Eugene Luksha: Glucose sensor. Cardiac Pacemakers, Orrin M Haugen, Thomas J Nikolai, July 14, 1987: US04679562 (313 worldwide citation)

A glucose sensor for electrically determining blood glucose concentration for in vivo and in vitro applications and comprising an iridium substrate with an oxidized surface, to which is bonded a first film of silanized gamma propyltriethoxysilane and a second film of glucose oxidase covalently bonde ...


8
Bruce A Tockman, Julio C Spinelli, Rodney W Salo: Method and apparatus to automatically optimize the pacing mode and pacing cycle parameters of a dual chamber pacemaker. Cardiac Pacemakers, Haugen and Nikolai P A, July 30, 1996: US05540727 (308 worldwide citation)

A cardiac stimulating system incorporating a microprocessor-based controller is designed to automatically optimize both the pacing mode and one or more pacing cycle parameters in a way that results in optimization of a cardiac performance parameter, such as cardiac output. For each of a plurality of ...


9
Roger W Dahl, Jayne G Fangel, David K Swanson: Subcutaneous shunted coil electrode. Cardiac Pacemakers, Haugen and Nikolai, November 22, 1994: US05366496 (305 worldwide citation)

A body implantable cardioversion/defibrillation device includes an electrically conductive lead, three lead extensions coupled to the lead through a junction body, and an electrode array consisting of three electrodes, one electrode being coupled to each of the lead extensions. Each electrode has se ...


10
Lawrence S Baumann, Bruce A Tockman, Rodney W Salo, Emanuel H Silvermint: Apparatus and method for optimizing cardiac performance by determining the optimal timing interval from an accelerometer signal. Cardiac Pacemakers, Haugen & Nikolai PA, November 17, 1998: US05836987 (305 worldwide citation)

A cardiac stimulating apparatus and method which optimizes cardiac performance by determining, from a filtered waveform transmitted from an accelerometer contained within the cardiac pacer, an optimum timing interval between at least one of intrinsic and paced stimulations of pre-selected chambers o ...



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