1
Robert J Sweeney, Bruce H KenKnight: Cardiac rhythm management system with arrhythmia prediction and prevention. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, August 7, 2001: US06272377 (449 worldwide citation)

A cardiac rhythm management system predicts when an arrhythmia will occur and in one embodiment invokes a therapy to prevent or reduce the consequences of the arrhythmia. A cardiac arrhythmia trigger/marker is detected from a patient, and based on the trigger/marker, the system estimates a probabili ...


2
James E Leslie, Everett D Anderson: Ambulatory infusion pump having programmable parameters. Cardiac Pacemakers, Orrin M Haugen, Thomas J Nikolai, Douglas L Tschida, July 16, 1985: US04529401 (431 worldwide citation)

A portable infusion pump for controllably supplying a programmed volume of medicant to a patient. The apparatus generally comprises a small, portable container having a keyboard for programming the mode of operation and operating parameters, whereby a microprocessor controls the pump in the various ...


3
Jesse W Hartley, Marc H Cohen, Nicholas J Stessman, Scott A Reedstrom, Steven D Check, James P Nelson: Rate adaptive cardiac rhythm management device using transthoracic impedance. Cardiac Pacemakers, Schwegman Lundberg Woessner and Kluth, June 13, 2000: US06076015 (370 worldwide citation)

A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A tra ...


4
Roger W Dahl, Robert W Wickham deceased, David K Swanson, David Lipson: Stent-type defibrillation electrode structures. Cardiac Pacemakers, Haugen and Nikolai, July 2, 1996: US05531779 (341 worldwide citation)

Implantable electrode structures for use in apparatus for applying electrical therapy to a patient's heart in the treatment of arrhythmias such as tachycardias and fibrillations of the heart are herein disclosed. The electrode structures are made in the form of expandable (or self-expanding) intrava ...


5
Weimin Sun, Thomas M Castellano, Russ E Anderson, Wade A Bowe, John A Simpson, Marshall L Sherman, Kathryn E Lockwood: RF ablation apparatus and method having electrode/tissue contact assessment scheme and electrocardiogram filtering. Cardiac Pacemakers, Fulwider Patton Lee & Utecht, May 21, 2002: US06391024 (336 worldwide citation)

A method of assessing the adequacy of contact between an ablation electrode and biological tissue within a biological organ having biological fluid therein includes the steps of positioning the ablation electrode proximal the biological tissue; positioning a reference electrode a distance from the a ...


6
Eugene Luksha: Glucose sensor. Cardiac Pacemakers, Orrin M Haugen, Thomas J Nikolai, July 14, 1987: US04679562 (318 worldwide citation)

A glucose sensor for electrically determining blood glucose concentration for in vivo and in vitro applications and comprising an iridium substrate with an oxidized surface, to which is bonded a first film of silanized gamma propyltriethoxysilane and a second film of glucose oxidase covalently bonde ...


7
Gerrard M Carlson, Veerichetty A Kadhiresan, Julio C Spinelli: Heart rate variability as an indicator of exercise capacity. Cardiac Pacemakers, Nikolai Merserau & Dietz P A, February 15, 2000: US06026320 (318 worldwide citation)

Based upon patient studies indices a high degree of correlation was found between HRV and VO2.sub.max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient' ...


8
Imad Libbus, Bruce H KenKnight, Julia Moffitt, Yatheendhar D Manicka: Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device. Cardiac Pacemakers, Schwegman Lundberg Woessner & Kluth P A, August 21, 2007: US07260431 (311 worldwide citation)

A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the delete ...


9
Bruce A Tockman, Julio C Spinelli, Rodney W Salo: Method and apparatus to automatically optimize the pacing mode and pacing cycle parameters of a dual chamber pacemaker. Cardiac Pacemakers, Haugen and Nikolai P A, July 30, 1996: US05540727 (309 worldwide citation)

A cardiac stimulating system incorporating a microprocessor-based controller is designed to automatically optimize both the pacing mode and one or more pacing cycle parameters in a way that results in optimization of a cardiac performance parameter, such as cardiac output. For each of a plurality of ...


10
Rodney W Salo, Brian D Pederson: Dimension sensitive angioplasty catheter. Cardiac Pacemakers, Orrin M Haugen, Thomas J Nikolai, May 13, 1986: US04587975 (309 worldwide citation)

An improved dilation catheter for use in the conduct of transluminal angioplasty techniques whereby measurements may be taken to determine patency during the course of the procedure. The catheter comprises an elongated tubular member having an inelastic expander member proximate its distal end. The ...



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