1
Hendricus R J M Hoogenboom, Michael Baier, Laurent S A T Jespers, Gregory P Winter: Production of chimeric antibodies - a combinatorial approach. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 15, 1996: US05565332 (754 worldwide citation)

Methods are disclosed which may be used for the production of antibodies, or antibody fragments, which have the same binding specificity as a parent antibody but which have increased human characteristics. Humanized antibodies may be obtained by chain shuffling, perhaps using phage display technolog ...


2
John McCafferty, Anthony Richard Pope, Kevin Stuart Johnson, Henricus Renerus Jacobus Mattheus Hoogenboom, Andrew David Griffiths, Ronald Henry Jackson, Kaspar Philipp Holliger, James David Marks, Timothy Piers Clackson, David John Chiswell, Gregory Paul Winter, Timothy Peter Bonnert: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 19, 1999: US05969108 (512 worldwide citation)

A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containi ...


3
Kevin Stuart Johnson, Gregory Paul Winter, Andrew David Griffiths, Andrew John Hammond Smith, Peter Michael Waterhouse: Methods for producing members of specific binding pairs. Cambridge Antibody Technology, Medical Research Council, Marshall O Toole Gerstein Murray & Borun, March 31, 1998: US05733743 (501 worldwide citation)

Methods, recombinant host cells and kits are disclosed for the production of members of specific binding pairs (sbp), e.g. antibodies, using display on the surface of secreted replicable genetic display packages (rgdps), e.g. filamentous phage. To produce a library of great diversity, recombination ...


4
Andrew David Griffiths, Hendricus Renerus Jacobus Mattheus Hoogenboom, James David Marks, John McCafferty, Gregory Paul Winter, Geoffrey Walter Grigg: Production of anti-self antibodies from antibody segment repertoires and displayed on phage. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, March 23, 1999: US05885793 (294 worldwide citation)

Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous ...


5
Kaspar Philipp Holliger, Andrew David Griffiths, Hendricus Renerus Jacobus Matheus Hoogenboom, Magnus Malmqvist, James David Marks, Brian Timothy McGuinness, Anthony Richard Pope, Terence Derek Prospero, Gregory Paul Winter: Multivalent and multispecific binding proteins, their manufacture and use. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, November 17, 1998: US05837242 (201 worldwide citation)

Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to ...


6
John McCafferty, Anthony Richard Pope, Kevin Stuart Johnson, Henricus Renerus Jacobus Mattheus Hoogenboom, Andrew David Griffiths, Ronald Henry Jackson, Kaspar Philipp Holliger, James David Marks, Timothy Piers Clackson, David John Chiswell, Gregory Paul Winter, Timothy Peter Bonnert: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O&apos Toole Gerstein Murray & Borun, January 9, 2001: US06172197 (165 worldwide citation)

A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containi ...


7
Gregory Paul Winter, Kevin Stuart Johnson, Andrew David Griffiths, Andrew John Hammond Smith: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, February 16, 1999: US05871907 (158 worldwide citation)

The invention provides methods and kits for producing specific binding pairs (sbp) members. Populations of polypeptide chain components of sbp members are combined to form libraries of sbps displayed by secreted replicable genetic display packages (rgdp). At least one of the polypeptide chains is ex ...


8
Geertruida M Veldman, Monique V Davies, Kening Song, Neil M Wolfman, Kristie Grove Bridges, Anne Field, Caroline Russell, Viia Valge Archer: Neutralizing antibodies against GDF-8 and uses therefor. Wyeth, Cambridge Antibody Technology, Finnegan Henderson Farabow Garrett & Dunner L, August 28, 2007: US07261893 (107 worldwide citation)

The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating dege ...


9
Gregory Paul Winter, Kevin Stuart Johnson, Andrew David Griffiths, Andrew John Hammond Smith: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, January 12, 1999: US05858657 (105 worldwide citation)

The invention provides methods and kits for producing specific binding pairs (sbp) members. Populations of polypeptide chain components of sbp members are combined to form libraries of sbps displayed by secreted replicable genetic display packages (rgdp). At least one of the polypeptide chains is ex ...


10
Andrew David Griffiths, Hendricus Renerus Jacobus Mattheus Hoogenboom, James David Marks, John McCafferty, Gregory Paul Winter, Geoffrey Walter Grigg: Production of anti-self antibodies from antibody segment repertoires and displayed on phage. Medical Research Council, Cambridge Antibody Technology, Katten Muchin Zavis Rosenman, February 18, 2003: US06521404 (89 worldwide citation)

Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous ...