1
John Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, August 24, 1999: US05942443 (533 worldwide citation)

Microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.


2
Anne R Kopf Sill, John Wallace Parce: Microfluidic systems incorporating varied channel dimensions. Caliper Technologies Corporation, Matthew B Murphy, December 1, 1998: US05842787 (452 worldwide citation)

The present invention is generally directed to improved microfluidic devices, systems and methods of using same, which incorporate channel profiles that impart significant benefits over previously described systems. In particular, the presently described devices and systems employ channels having, a ...


3
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, April 4, 2000: US06046056 (423 worldwide citation)

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and ...


4
John Wallace Parce, Michael R Knapp, Calvin Y H Chow, Luc Bousse: Controlled fluid transport in microfabricated polymeric substrates. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, March 23, 1999: US05885470 (324 worldwide citation)

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have ...


5
Calvin Y H Chow, J Wallace Parce: Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces. Caliper Technologies Corporation, Townsend and Townsend and Crew, September 1, 1998: US05800690 (303 worldwide citation)

In a microfluidic system using electrokinetic forces, the present invention uses electrical current or electrical parameters, other than voltage, to control the movement of fluids through the channels of the system. Time-multiplexed power supplies also provide further control over fluid movement by ...


6
J Wallace Parce, Michael R Knapp: Electropipettor and compensation means for electrophoretic bias. Caliper Technologies Corporation, Townsend and Townsend and Crew, July 14, 1998: US05779868 (252 worldwide citation)

The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The materials are transported in slug regions of high ionic concentration, next to buffer material regions of high ionic concentration, which are separa ...


7
J Wallace Parce, Michael R Knapp: Electropipettor and compensation means for electrophoretic bias. Caliper Technologies Corporation, Townsend and Townsend and Crew, March 9, 1999: US05880071 (249 worldwide citation)

The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, whi ...


8
Calvin Y H Chow, J Wallace Parce: Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces. Caliper Technologies Corporation, Townsend and Townsend and Crew, October 12, 1999: US05965001 (195 worldwide citation)

In a microfluidic system using electrokinetic forces, the present invention uses electrical current or electrical parameters, other than voltage, to control the movement of fluids through the channels of the system. Time-multiplexed power supplies also provide further control over fluid movement by ...


9
J Wallace Parce: Fourier detection of species migrating in a microchannel. Caliper Technologies Corporation, Townsend and Townsend and Crew, December 22, 1998: US05852495 (176 worldwide citation)

The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light from periodically spaced regions along a channel in the microfluidic ...


10
Robert Nagle, Colin B Kennedy: Microfluidic devices and systems incorporating integrated optical elements. Caliper Technologies Corporation, Townsend and Townsend and Crew, August 8, 2000: US06100541 (173 worldwide citation)

The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulatio ...



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