1
Jaeschke Andres, Hausch Felix: Multiplex sequence variation analysis of dna samples by mass spectrometry. Bruker Saxonia Analytik, October 4, 2001: EP1138782-A2 (72 worldwide citation)

The invention relates to the simultaneous analysis of variations in distinct nucleic acid sequences within a complex nucleic acid mixture. The invention consists in the use of chips with spatially separated fields of photocleavable oligonucleotide probes which are commonly processed together with th ...


2
Kostrzewa Markus, Froehlich Thomas, Wenzel Thomas, Jaeschke Andreas, Hausch Felix: Mutation analysis by mass spectrometry using photolytically cleavable primers. Bruker Saxonia Analytik, August 28, 2002: EP1234888-A2 (67 worldwide citation)

The invention relates to a method of a mass-spectrometric analysis of known mutation sites in the genome, such as single nucleotide polymorphisms (SNPs), using the method of restricted primer extension. The invention consists of the use of primers with a photocleavable linker. The linker creates a g ...


3
Hans Rudiger Doring, Stefan Klepel, Jorg Peuker, Roland Schnurpfeil, Gerhard Weiss: Ion mobility spectrometer with switchable electrodes. Bruker Saxonia Analytik, August 22, 2000: US06107624 (32 worldwide citation)

The invention relates to a switchable ion mobility spectrometer (IMS) with ring electrodes divided into half-rings, which surround the drift chamber of the IMS. In a first operating condition, the two half-rings of each ring electrode are at the same potential and the various ring electrodes are at ...


4
Manfred Karl: Ion mobility spectrometer drift chamber. Bruker Saxonia Analytik, Cesari and McKenna, January 18, 1994: US05280175 (31 worldwide citation)

The invention concerns a gas tight drift chamber of an ion mobility spectrometer with ring electrodes separated by insulating rings. In order to simplify the construction and to improve the mechanical and electrical stability, the ring electrodes have a z-shaped cross section, into which the insulat ...


5
Hans Rüdiger Döring: Ion mobility spectrometer with mechanically stabilized vacuum-tight x-ray window. Bruker Saxonia Analytik, May 25, 2004: US06740874 (26 worldwide citation)

An ion mobility spectrometer (IMS) has a non-radioactive electron source and an x-ray anode in an evacuated chamber. The impinging of electrons from the source on the anode results in the generation of x-ray radiation. The x-ray radiation passes through a window that provides a vacuum barrier betwee ...


6
Jochen Franzen: Method of measuring ion mobility spectra. Bruker Saxonia Analytik, February 17, 1998: US05719392 (24 worldwide citation)

A method for measuring the mobility spectra of ions with ion mobility spectrometers (IMS). The method consists of impressing upon the essentially continuous ion flow of an IMS ion source, which comprises various ion types with various mobitities, a temporal switching signature with an ion admission ...


7
Hans Rudiger Doring, Gerd Arnold, Joachim Adler, Thomas Robel, Jurgen Riemenschneider: Photo-ionization ion mobility spectrometry. Bruker Saxonia Analytik, October 19, 1999: US05968837 (23 worldwide citation)

In a method for photo-ionization ion mobility spectrometry, a reagent gas is added, in particular an aromatic compound, which has a large ionization cross section in the range of ionizing VUV radiation, but a low probability for the formation of protonated quasi-molecular ions. In this way, the dete ...


8
Hans Rüdiger Döring: Ionization chamber with electron source. Bruker Saxonia Analytik, August 6, 2002: US06429426 (16 worldwide citation)

Ionization chamber, especially for an ion mobility spectrometer, with a non-radioactive electron source. The chamber consists of two compartments, of which one is evacuated and contains an electron source, and the other represents the reaction chamber of the IMS. In the evacuated compartment, X-ray ...


9
Wolfgang Heller, Boris Grigorjewitsch Titov, Gerd Arnold: Analysis system for non-destructive identification of explosives and chemical warfare agents. Bruker Saxonia Analytik, May 21, 2002: US06393085 (15 worldwide citation)

The invention relates to an analyzer for the identification of explosives and/or chemical warfare agents, with a neutron source which causes the emission of characteristic &ggr; quanta, whereby the analysis system consists of a mobile frame to which a neutron source and a detector as well as a holde ...


10
Vitali Lvovich Budovich, Alexei Anatolevich Mikhailov, Gerd Arnold: Ion mobility spectrometer. Bruker Saxonia Analytik, October 19, 1999: US05969349 (11 worldwide citation)

Ion mobility spectrometer with a non-radioactive electron source to generate ions inside a reaction chamber. The reaction chamber consists of two partial chambers, one of which is evacuated and comprises the electron source, and the other one is connected to the drift chamber of the IMS via a shutte ...