1
Patrick Aebischer, Shelley R Winn, Pierre M Galletti: In vivo delivery of neurotransmitters by implanted, encapsulated cells. Brown University Research Foundation, Thomas J Engellenner, Ann Louise Kerner, January 9, 1990: US04892538 (319 worldwide citation)

Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter there ...


2
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Brown University, Ivor R Elrifi, John Prince, Mintz Levin Cohn Ferris Glovsky and Popeo P C, July 4, 2000: US06083523 (288 worldwide citation)

An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, p ...


3
Robert F Valentini: Negatively charged polymeric electret implant. Brown University Research Foundation, Thomas J Engellenner, Scott D Lahive & Cockfield Rothenberger, June 2, 1998: US05759205 (255 worldwide citation)

A biocompatible implant having improved host tissue ingrowth capability and enhanced blood compatibility comprises at least one tissue-contacting surface of an electrically charged material. The electrically charged material can be further chemically modified with covalently bonded activator molecul ...


4
Patrick Aebischer, Pierre M Galletti, George Panol, Luigi Miracoli: Implantable delivery system for biological factors. Brown University Research Foundation, Thomas J Engellener, April 30, 1991: US05011472 (206 worldwide citation)

Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secre ...


5
Patrick Aebischer, Paul C DiCesare, Moses Goddard, Paul J Mulhauser: Renewable neural implant device and method. Brown University Research Foundation, James F Haley Jr Esq, Ivor R Fish & Neave Elrifi Esq, September 10, 1996: US05554148 (201 worldwide citation)

Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber adapted for infusion with nsecretory cells and having at least one semipermeable or permselective surface across whi ...


6
Jules S Jacob, Edith Mathiowitz: Methods and compositions for enhancing the bioadhesive properties of polymers. Brown University Research Foundation, Arnall Golden & Gregory, September 26, 2000: US06123965 (172 worldwide citation)

Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery devices. The bioadhesive properties of a polymer are enhanced by incorporating a metal compound into the polymer to enhance the ability of the polymer to adhere to a tissue surface such a ...


7
Humphrey J Maris, Robert J Stoner: Optical stress generator and detector. Brown University Research Foundation, Perman & Geen, May 5, 1998: US05748318 (171 worldwide citation)

Disclosed is a system for the characterization of thin films and interfaces between thin films through measurements of their mechanical and thermal properties. In the system light is absorbed in a thin film or in a structure made up of several thin films, and the change in optical transmission or re ...


8
Patrick Aebischer, Shelley R Winn: Neurological therapy devices. Brown University Research Foundation, Thomas J Engellenner, Ann Louise Kerner, April 21, 1992: US05106627 (166 worldwide citation)

Neurological therapy devices are disclosed for the local and controlled delivery of a neurotransmitter to the brain of a subject suffering from neurotransmitter deficiency or dysfunction. In one embodiment the device includes a biocompatible, implantable, and retrievable polymeric insert including a ...


9
Patrick Aebischer, Moses Goddard, John G Moldauer, Paul J Mulhauser, Anne M Rathbun, Paul R Sanberg, Alfred V Vasconcellos, Nicholas F Warner: Implantable therapy systems and methods. Brown University Research Foundation, Ivor R Elrifi, Barbara A Ruskin, Fish & Neave, January 30, 1996: US05487739 (165 worldwide citation)

Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, general ...


10
Patrick Aebischer, Lars Wahlberg: Cell culture-containing tubular capsule produced by co-extrusion. Brown University Research Foundation, Thomas J Engellenner, Matthew P Vincent, February 1, 1994: US05283187 (127 worldwide citation)

Living cells such as animal cells which produce biologically active factors are encapsulated within a semipermeable, polymeric membrane such as polyacrylate by co-extruding an aqueous cell suspension and a polymeric solution through a common port having at least one concentric bores to form a tubula ...