1
Tanamachi Dawn M, Brams Peter, Black Amelia: Transgenic animals expressing chimeric antibodies for use in preparing human antibodies. Medarex, Tanamachi Dawn M, Brams Peter, Black Amelia, GAVIN Kimberley A, October 18, 2007: WO/2007/117410 (50 worldwide citation)

The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin ...


2
Min Jing, Wu Yanli, Finn Rory Francis, Thiele Barrett Richard, Laio Wei, Gladue Ronald Paul, Rajpal Arvind, Paradis Timothy Joseph, Brams Peter, Devaux Brigitte, Wu Yi, Toy Kristopher, Leblanc Heidi N, Huang Haichun: Binding molecules to the human ox40 receptor. Medarex, Pfizer, Min Jing, Wu Yanli, Finn Rory Francis, Thiele Barrett Richard, Laio Wei, Gladue Ronald Paul, Rajpal Arvind, Paradis Timothy Joseph, Brams Peter, Devaux Brigitte, Wu Yi, Toy Kristopher, Leblanc Heidi N, Huang Haichun, BRADY James W, June 25, 2009: WO/2009/079335 (11 worldwide citation)

The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells comtaining the vectors, methods of making the binding molecules, pharmac ...


3
Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark: Alpha 5 - beta 1 antibodies and their uses. Medarex, Pfizer, Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark, BRADY James W, August 13, 2009: WO/2009/100110 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells ...


4
Rajpal Arvind, Devalaraja Madhav, Toy Kristopher, Yang Lan, Huang Halichun, Zhang Jun Z, Brams Peter, Devaux Brigitte, Passmore David B: Antibodies to il-6 and their uses. Medarex, Pfizer, Rajpal Arvind, Devalaraja Madhav, Toy Kristopher, Yang Lan, Huang Halichun, Zhang Jun Z, Brams Peter, Devaux Brigitte, Passmore David B, Brady James W, December 23, 2009: WO/2009/155180 (4 worldwide citation)

Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding port ...


5
Kuhne Michelle, Brams Peter, Tanamachi Dawn M, Korman Alan, Cardarelli Josephine M: Human antibodies that bind cxcr4 and uses thereof. Medarex, Kuhne Michelle, Brams Peter, Tanamachi Dawn M, Korman Alan, Cardarelli Josephine M, DECONTI Giulio A, May 22, 2008: WO/2008/060367 (3 worldwide citation)

The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of ...


6
Wang Yan, Greenberg Robert, Presta Leonard, Pachter Jonathan A, Hailey Judith, Brams Peter, Williams Denise, Srinivasan Mohan, Feingersh Diane: Neutralizing human anti-igfr antibody. Schering Corporation, Wang Yan, Greenberg Robert, Presta Leonard, Pachter Jonathan A, Hailey Judith, Brams Peter, Williams Denise, Srinivasan Mohan, Feingersh Diane, TRIOLO Thomas A, December 4, 2003: WO/2003/100008 (2 worldwide citation)

The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.


7
Vistica Cynthia A, Holmes Eric H, Brams Peter, Witte Alison, Cardarelli Josephine M: Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1. Medarex, Vistica Cynthia A, Holmes Eric H, Brams Peter, Witte Alison, Cardarelli Josephine M, PEPE Jeffrey C, June 14, 2007: WO/2007/067992 (1 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodi ...


8
Brams Peter: Method of manufacturing an article of jewelry having faux pave look. Brams Peter, LANGSAM Andrew S, May 30, 1996: WO/1996/015872

A method for producing an article of jewelry having a faux pavé diamond look. According to the method, at each location where a faux pavé diamond is desired, an upwardly extending cylinder (72) is located. The top circular surface (86) of the cylinder (72) is scored or chiseled, first across a diame ...


9
Anderson Darrell R, Hanna Nabil, Brams Peter: Identification of unique binding interactions between certain antibodies and the human b7.1 and b7.2 co-stimulatory antigens. Idec Pharmaceuticals Corporation, Anderson Darrell R, Hanna Nabil, Brams Peter, TESKIN Robin L, November 29, 2001: WO/2001/089567

The present invention relates to the identification of antibodies which are specific to B7 antigens, e.g. human B7.1 antigen (CD80) and/or B7.2 antigen (CD86), which promote apoptosis of B7+ cells, preferably B cells. Also preferably, such antibodies are capable of inhibiting the binding of B7.1 to ...


10
Coccia Marco Anthony, Brams Peter: Methods for producing human antibodies in scid mice using dendritic cells. Idec Pharmaceuticals Corporation, Coccia Marco Anthony, Brams Peter, GESS E Joseph, March 18, 1999: WO/1999/012553

An improved method for producing human antibodies in SCID mice is provided. The improvement includes the use of dendritic cells pulsed with antigen-antibody complexes and antigen-antibody complexes as immunizing agents.