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Tanamachi Dawn M, Brams Peter, Black Amelia: Transgenic animals expressing chimeric antibodies for use in preparing human antibodies. Medarex, Tanamachi Dawn M, Brams Peter, Black Amelia, GAVIN Kimberley A, October 18, 2007: WO/2007/117410 (50 worldwide citation)

The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin ...


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Cardarelli Josephine M, Black Amelia Nancy: Monoclonal antibodies against cd30 lacking fucosyl residues. Medarex, Cardarelli Josephine M, Black Amelia Nancy, DECONTI Giulio A, August 24, 2006: WO/2006/089232 (8 worldwide citation)

The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies ...


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Black Amelia Nancy, Passmore David B, Srinivasan Mohan, Dickey Lynn F, Cox Kevin M, Peele Charles G, Wang Ming Bo: Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues. Medarex, Black Amelia Nancy, Passmore David B, Srinivasan Mohan, Dickey Lynn F, Cox Kevin M, Peele Charles G, Wang Ming Bo, DECONTI Giulio A, July 26, 2007: WO/2007/084672 (6 worldwide citation)

The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to Iyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosy ...


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Black Amelia: Expression vector. Medarex, Black Amelia, FEHLNER Paul F, March 17, 2005: WO/2005/024015 (3 worldwide citation)

This invention provides nucleic acids and expression vectors, and host cells transformed with the same, for providing high expression of a desired polypeptide. Also provided are methods of using the expression vectors, nucleic acids, and host cells which have been modified by these compositions, for ...


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Deo Yashwant M, Graziano Robert, Hudson Debra, Holmes Eric H, Tino William T, Black Amelia: Human monoclonal antibodies to prostate specific membrane antigen (psma). Medarex, Deo Yashwant M, Graziano Robert, Hudson Debra, Holmes Eric H, Tino William T, Black Amelia, REMILLARD Jane E, August 7, 2003: WO/2003/064606

Isolated human monoclonal antibodies which bind to PSMA, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by unde ...