1
Harry Meade, Nils Lonberg: Isolation of exogenous recombinant proteins from the milk of transgenic mammals. Biogen, James F Haley Jr, Teresa L Solomon, October 10, 1989: US04873316 (317 worldwide citation)

This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system comprising the mammal's casein promoter which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desire ...


2
Leemans Jan, Botterman Johan, de Block Marc, Thompson Charles, Mouva Rao: Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering.. Plant Genetic Systems, Biogen, October 21, 1987: EP0242246-A1 (243 worldwide citation)

The invention relates to a DNA fragment containing a determined gene, the expression of which inhibits the antibiotic and herbicidal effects of Bialaphos and related products. It also relates to recombinant vectors, containing such DNA fragment, which enable this protective gene to be introduced and ...


3
Leemans Jan, Botterman Johan, de Block Marc, Thompson Charles, Maouva Rao: Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering.. Plant Genetic Systems, Biogen, October 21, 1987: EP0242236-A1 (173 worldwide citation)

The invention relates to a DNA fragment containing a determined gene, the expression of which inhibits the antibiotic and herbicidal effects of Bialaphos and related products. It also relates to recombinant vectors, containing such DNA fragment, which enable this protective gene to be introduced and ...


4
Alan Frankel, Carl Pabo, James G Barsoum, Stephen E Fawell, R Blake Pepinsky: Tat-derived transport polypeptides and fusion proteins. Biogen, Warren A Kaplan, Biogen, September 8, 1998: US05804604 (150 worldwide citation)

This invention relates to delivery of biologically active cargo molecules, such as polypeptides and nucleic acids, into the cytoplasm and nuclei of cells in vitro and in vivo. Intracellular delivery of cargo molecules according to this invention is accomplished by the use of novel transport polypept ...


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Kuzhalmannam L Ramachandran, Richard L Cate: Nucleic acid probe linked to a label having a terminal cysteine. Biogen, Leon R Yankwich, James F Haley Jr, April 28, 1992: US05109124 (127 worldwide citation)

A polynucleotide probe with a label bearing a plurality of signalling moieties. The label is attached to the probe by the reaction of an amino and sulfhydryl reactive hetero bifunctional reagent with the probe and label, the reaction resulting in the oxidation of a sulfhydryl group of the label. The ...


7
Weissmann Charles: Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides.. Biogen, July 15, 1981: EP0032134-A2 (115 worldwide citation)

DNA sequences, recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying a biological or immunological activity of human interferon, the genes coding for these polypeptides and methods of making and using these molecules, hosts, genes and polypeptides. The DNA s ...


8
Charles Weissmann: Recombinant DNA molecules and their use in producing human interferon-like polypeptides. Biogen, James F Haley Jr, July 23, 1985: US04530901 (108 worldwide citation)

Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying a biological or immunological activity of human interferon, the gene coding for these polypeptides and methods of making and using these molecules, hosts, genes and polypeptides. The recombinant DNA molec ...


9
Darrell R Anderson, Nabil Hanna, Roland A Newman, Mitchell E Reff, William H Rastetter: Anti-CD20 antibodies. Biogen Idec, Sidley Austin, September 9, 2008: US07422739 (83 worldwide citation)

Disclosed are chimeric, immunologically active, isolated, and radiolabeled antibodies directed against the CD20 antigen. The antibodies are useful for treating and diagnosing B cell disorders.


10
Jan Leemans, Johan Botterman, Marc De Block, Charles Thompson, Rao Mouva: Genetically engineered plant cells and plants exhibiting resistance to glutamine synthetase inhibitors, DNA fragments and recombinants for use in the production of said cells and plants. Bayer BioScience, Biogen, Buchanan Ingersoll PC, September 26, 2006: US07112665 (74 worldwide citation)

The invention relates to a DNA fragment containing a determined gene, the expression of which inhibits the antibiotic and herbicidal effects of Bialaphos and related products. It also relates to recombinant vectors, containing such DNA fragment, which enable this protective gene to be introduced and ...