1
Esau Christine, Lollo Bridget, Bennett C Frank, Freier Susan M, Griffey Richard H, Baker Brenda F, Vickers Timothy, Marcusson Eric G, Koller Erich, Swayze Eric E, Jain Ravi, Bhat Balkrishen, Peralta Eigen: Oligomeric compounds and compositions for use in modulation of small non-coding rnas. Isis Pharmaceuticals, Esau Christine, Lollo Bridget, Bennett C Frank, Freier Susan M, Griffey Richard H, Baker Brenda F, Vickers Timothy, Marcusson Eric G, Koller Erich, Swayze Eric E, Jain Ravi, Bhat Balkrishen, Peralta Eigen, LEGAARD Paul K, February 17, 2005: WO/2005/013901 (113 worldwide citation)

Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targ ...


2
Prakash Thazha P, Swayze Eric E, Bhat Balkrishen: N-substituted-aminomethylene bridged bicyclic nucleic acid analogs. Isis Pharmaceuticals, Prakash Thazha P, Swayze Eric E, Bhat Balkrishen, PATHAK Rahul, December 11, 2008: WO/2008/150729 (86 worldwide citation)

Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bi cyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful fo ...


3
Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 22, 2004: WO/2004/007512 (75 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


4
Bhat Balkrishen, Migawa Michael T, Swayze Eric E: 5-substituted-2-f modified nucleosides and oligomeric compounds prepared therefrom. Isis Pharmaceuticals, Bhat Balkrishen, Migawa Michael T, Swayze Eric E, RIEGER Dale, August 21, 2008: WO/2008/101157 (75 worldwide citation)

The present invention provides 5'-substituted-2'-F nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In one preferred embodiment the nucleoside analogs have either (R) or (5)-chirality at the 5'-position. These nucleoside analogs are expected to be useful for enhancing ...


5
Olsen David B, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Olsen David B, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 8, 2004: WO/2004/003138 (71 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


6
Bhat Balkrishen, Prakash Thazha P, Dande Prasad, Allerson Charles, Griffey Richard, Swayze Eric E: Double strand compositions comprising differentially modified strands for use in gene modulation. Isis Pharmaceuticals, Bhat Balkrishen, Prakash Thazha P, Dande Prasad, Allerson Charles, Griffey Richard, Swayze Eric E, CALDWELL John, December 22, 2005: WO/2005/121371 (70 worldwide citation)

The present invention provides douse stranded compositions wherein each strand is modified to have a motif defined by positioning of ß-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a g ...


7
Butora Gabor, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B: C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Butora Gabor, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 29, 2005: WO/2005/123087 (53 worldwide citation)

The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are ...


8
Olsen David B, Bhat Balkrishen, Cook Phillip Dan: Pyrrolopyrimidine thionucleoside analogs as antivirals. Merck & Co, Isis Pharmaceuticals, Olsen David B, Bhat Balkrishen, Cook Phillip Dan, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 29, 2004: WO/2004/009020 (52 worldwide citation)

The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are pa ...


9
Carroll Steven S, Olsen David B, Durette Philippe L, Bhat Balkrishen, Dande Prasad, Eldrup Anne B: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Carroll Steven S, Olsen David B, Durette Philippe L, Bhat Balkrishen, Dande Prasad, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 31, 2003: WO/2004/000858 (51 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


10
Esau Christine, Swayze Eric E, Bhat Balkrishen, Kinberger Garth A: Oligomeric compounds and compositions for the use in modulation of micrornas. Isis Pharmaceuticals, Esau Christine, Swayze Eric E, Bhat Balkrishen, Kinberger Garth A, BOSWELL Herb, August 9, 2007: WO/2007/090073 (33 worldwide citation)

Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibi ...