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Beppu Teruhiko, Uozumi Takeshi, Nishimori Katsuhiko, Shimizu Norio, Kawaguchi Yoshiyuki, Hidaka Makoto: Novel expression plasmids and their use in the method for expressing prochymosin coding gene in e. coli.. Beppu Teruhiko, October 17, 1984: EP0121775-A1 (79 worldwide citation)

Improved methods are provided for replication and expression of prochymosin coding gene in E. coli. Novel expression plasmids having prochymosin coding gene operatively attached to the E. coli trp operon have been developed. These plasmids have been inserted into E. coli host cells by transformation ...


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Beppu Teruhiko, Horinouchi Sueharu, Nishiyama Makoto, Yu Fujio, Hashimoto Yoshihiro: Hybrid plasmid vectors containing genes encoding nitrile degrading enzymes and methods of producing amides and acids.. Nitto Chemical, Beppu Teruhiko, September 9, 1992: EP0502476-A2 (43 worldwide citation)

The present invention provides a recombinant plasmid comprising combining a hybrid plasmid vector with the isolated DNA sequences of one or more genes encoding nitrile degrading enzymes which are derived from bacteria belonging to the genus Rhodococcus, said hybrid plasmid vector comprising an isola ...


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Beppu Teruhiko, Yamada Hideaki, Nagasawa Toru Dr, Horinouchi Sueharu, Nishiyama Makoto Dr: Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the dna fragment and a process for the production of amides using the transformant.. Nitto Chemical, Beppu Teruhiko, Hideaki Yamada, September 11, 1991: EP0445646-A2 (21 worldwide citation)

The present invention discloses the amino acid sequence and nucleotide sequence of the alpha - and beta -subunits of two types of nitrile hydratase derived from Rhodococcus rhodochrous J-l. The DNA fragment encoding nitrile hydratase is inserted into an expression vector and the recombinant vector i ...


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Beppu Teruhiko, Uozumi Takeshi, Nishimori Katsuhiko: Recombinant plasmid and microorganism containing same.. Beppu Teruhiko, March 2, 1983: EP0073029-A2 (16 worldwide citation)

Messenger RNA of prorennin is extracted from the fourth stomach of calf and the double-stranded prorennin cDNA is prepared thereform. The prorennin cDNA is cloned into a host microorganism, E. coli C600r@m@, to give clones containing the cDNA insert with variable size as confirmed by the base sequen ...


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Beppu Teruhiko, Iwamoto Yasushi, Yoshida Minoru: Trichostatins a and c as antitumour drugs.. Beppu Teruhiko, October 8, 1986: EP0196415-A2 (7 worldwide citation)

Use of trichostatin A and/or trichostatin C for the manufacture of an antitumour drug.


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Beppu Teruhiko, Yamada Hideaki, Nagasawa Toru, Horinouchi Sueharu, Nishiyama Makoto: A gene encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant.. Nitto Chemical, Beppu Teruhiko, Hideaki Yamada, September 4, 1991: EP0444639-A2 (4 worldwide citation)

The present invention relates to a gene derived from Pseudomonas chlororaphis B23 strain which encodes a polypeptide having nitrile hydratase activity being capable of hydrating nitriles to amides. The invention also relates to a recombinant DNA containing the gene, and a transformant transformed wi ...


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Beppu Teruhiko, Uozumi Takeshi, Tsuchiya Makoto, Sekine Susumu: Expression plasmids useful in b. subtilis.. Beppu Teruhiko, September 11, 1985: EP0154351-A2 (2 worldwide citation)

A new vector system is described for expression of prochymosin in B. subtilis. The vector system includes the prochymosin encoding gene and an erythromycin resistant promotor and can be integrated into a B. subtilis host organism as an expression plasmid adapted for transformation.


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