1
Bosslet Klaus Dr, Hermentin Peter Dr, Seemann Gerhard Dr, Kuhlmann Ludwig Dr, Steinstraesser Axel Dr Dr: Bispecific and oligospecific, mono- and oligovalent receptors, production and applications thereof.. Behringwerke, December 27, 1990: EP0404097-A2 (285 worldwide citation)

The invention relates to bispecific and oligospecific, mono- and oligovalent receptors which are prepared by genetic manipulation by fusion of DNA coding for F(ab) fragments of the antibodies of two or more different specificities, using suitable linkers. Preferably one of these specificities is dir ...


2
Heinz Jurgen Friesen, Gerd Grenner, Hans Erwin Pauly, Helmut Kohl, Klaus Habenstein, Joseph Stark: Sheet-like diagnostic device. Behringwerke Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner, August 29, 1989: US04861711 (200 worldwide citation)

A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several f ...


3
Lauffer Leander Dr, Oquendo Patricia Dr, Zettlmeissl Gerd Dr, Seed Brian Dr: Fusionproteins with parts of immunoglobulins, their production and use.. Behringwerke, Gen Hospital, January 8, 1992: EP0464533-A1 (122 worldwide citation)

The invention relates to genetically engineered soluble fusion proteins consisting of human proteins or parts thereof not belonging to the immunoglobulin family and various portions of the constant region of immunoglobulin molecules. The functional properties of both fusion components are surprising ...


4
Klaus Bosslet, Peter Hermentin, Gerhard Seemann, Ludwig Kuhlmann, Axel Steinstr asser: Bispecific and oligospecific mono-and oligovalent receptors, the preparation and use thereof. Behringwerke Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, January 7, 1997: US05591828 (121 worldwide citation)

The invention relates to bispecific and oligospecific, mono- and oligovalent receptors which are prepared by gene manipulation by fusion of DNA coding for F(ab) fragments of antibodies of two or more different specificities by means of suitable linkers. In this connection, one specificity is prefera ...


5
Andrzej Grzegorzewski: Biosensor for measuring changes in viscosity and/or density of a fluid. Behringwerke Aktiengesellschaft, Spencer Frank & Schneider, February 27, 1996: US05494639 (99 worldwide citation)

A disposable biosensor for measuring changes in viscosity and/or density in a test fluid includes a disposable housing surrounding a measuring chamber. A piezoelectric element is disposed in the measuring chamber and constitutes an oscillating unit. The piezoelectric element has a measuring surface ...


6
Horst Schwinn, Norbert Heimburger, Gerhardt Kumpe, Bernd Herchenhan: Blood coagulation factors and process for their manufacture. Behringwerke Aktiengesellschaft, Curtis Morris & Safford, October 27, 1981: US04297344 (96 worldwide citation)

A process for stabilizing the coagulation factors II, VIII, XIII, antithrombin III and plasminogen against heat is described. The preparations obtained according to this process are practically free from coagulable fibrinogen.


7
Klaus Bosslet, Gerhard Seemann: Tetravalent bispecific receptors, the preparation and use thereof. Behringwerke Aktiengellschaft, Finnegan Henderson Farabow Garrett & Dunner L, September 28, 1999: US05959083 (87 worldwide citation)

The invention relates to bispecific tetravalent receptors of the formula I ##STR1## or formula II ##STR2## against a tumor-associated antigen and against an agent active against tumors.


8
Maureen Laney, Yan Chen, Edwin F Ullman, Karen M Hahnenberger: Method for introducing defined sequences at the 3end of polynucleotides. Behringwerke, Theodore J Leitereg, October 21, 1997: US05679512 (86 worldwide citation)

A method is disclosed for extending a primer to produce a single stranded polydeoxynucleotide that has two or more defined sequences. A combination is provided which comprises a template polynucleotide, a blocker polynucleotide, a primer polynucleotide and a polynucleotide Q. The template polynucleo ...


9
Peter Fuhge, Norbert Heimburger, Hans Arnold Stohr, Wolfgang Burk: Readily dissolvable lyophilized fibrinogen formulation. Behringwerke Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner, March 17, 1987: US04650678 (77 worldwide citation)

A solid fibrinogen formulation is described, which formulation contains, in addition to fibrinogen, a substance containing the urea or guanidine radical, and a process for its preparation. This formulation is used for the preparation of a fibrinogen solution which is suitable as an adhesive for huma ...


10
Thomas Pfeifer, Dietmar Weitzel, Wolfgang Kneip, Bernhard Vohwinkel, Axel von Brand: Component mixing apparatus and system including a movable cannula. Behringwerke Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, April 28, 1998: US05743312 (69 worldwide citation)

An apparatus for combining liquid or solid components stored in containers includes a cylindrical hollow body for receiving end closures of the containers and at least one cannula for penetrating the end closures. The cannula is mounted in a cannula holder movable in the hollow body, and retainer br ...