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Hadida, Ruah Sara, Hamilton Matthew, Miller Mark, Grootenhuis Peter D J, Bear Brian, Mccarthy Jason, Zhou Jinglan: Heterocyclic modulators of atp-binding cassette transporters. Vertex Pharmaceuticals Incorporated, Hadida, Ruah Sara, Hamilton Matthew, Miller Mark, Grootenhuis Peter D J, Bear Brian, Mccarthy Jason, Zhou Jinglan, LIU Yi, May 18, 2007: WO/2007/056341 (29 worldwide citation)

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods ...


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Ruah Sara S Hadida, Grootenhuis Peter Dj, Van, Goor Frederick, Zhou Jinglan, Bear Brian, Miller Mark T, Mccartney Jason, Numa Mehdi Michel Jamel: Modulators of atp-binding cassette transporters. Vertex Pharmaceuticals Incorporated, Ruah Sara S Hadida, Grootenhuis Peter Dj, Van, Goor Frederick, Zhou Jinglan, Bear Brian, Miller Mark T, Mccartney Jason, Numa Mehdi Michel Jamel, O BRIEN Jonathan P, October 18, 2007: WO/2007/117715 (21 worldwide citation)

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods o ...


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BEAR Brian W, LE Thu Anh, LYTLE Thomas W, OVERMYER Mark D, SETSER Michael, SMITH Bret W, ZAVATSKY Joseph, MODI Kreena: [fr] DISPOSITIF DAPPLICATION DUN AGENT ADJUVANT DANS UNE PROCÉDURE ENDOSCOPIQUE, [en] DEVICE FOR APPLYING ADJUNCT IN ENDOSCOPIC PROCEDURE. BEAR Brian W, LE Thu Anh, LYTLE Thomas W, OVERMYER Mark D, SETSER Michael, SMITH Bret W, ZAVATSKY Joseph, MODI Kreena, ETHICON ENDO SURGERY, JOHNSON Philip S, February 14, 2013: WO/2013/023114 (13 worldwide citation)

[en] A modular end effector delivers a therapeutic agent onto tissue that has been severed and/or stapled. The end effector is removably attached to a device. The device applies force to a piston of the end effector. The force causes a distal movement of a piston along a wall disposed within the end ...


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Ruah Sara S Hadida, Miller Mark T, Bear Brian, Mccartney Jason, Grootenhuis Peter D J: (phenyl) Cyclopropane- carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis. Vertex Pharmaceuticals Incorporated, Ruah Sara S Hadida, Miller Mark T, Bear Brian, Mccartney Jason, Grootenhuis Peter D J, O BRIEN Jonathan P, August 2, 2007: WO/2007/087066 (11 worldwide citation)

A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: Each R1 is independently an optionally substituted C1-6 aliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted C3-10 membered cycloaliphatic or an optionally substitu ...


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Hadida, Ruah Sara, Grootenhuis Peter Dj, Zhou Jinglan, Bear Brian, Miller Mark, Mccartney Jason: Modulators of cftr. Vertex Pharmaceuticals Incorporated, Hadida, Ruah Sara, Grootenhuis Peter Dj, Zhou Jinglan, Bear Brian, Miller Mark, Mccartney Jason, DIVERDI Michael J, November 20, 2008: WO/2008/141119 (9 worldwide citation)

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods ...


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