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Anderson Donald Carroll, Rothlein Robert, Smith Clinton Wayne, Barton Randall Wilbur: Use of icam-1 or its functional derivatives for the treatment of non-specific inflammation.. Baylor College Medicine, Boehringer Ingelheim Pharma, May 10, 1989: EP0314863-A2 (82 worldwide citation)

The invention provides a method for treating inflammation caused by the non-specific defense system of a mammalian subject. Inflammation is treated by providing the subject with an anti-inflammatory agent capable of inhibiting granulocyte-endothelial cell adhesion.


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Hogan Michael Edward, Kessler Donald Joseph: Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use.. Baylor College Medicine, June 27, 1990: EP0375408-A1 (72 worldwide citation)

A method for making synthetic oligonucleotides which bind to target sequences in a duplex DNA forming colinear triplexes by binding to the major groove. The method includes scanning genomic duplex DNA and identifying nucleotide target sequences of greater than about 20 nucleotides having either abou ...


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Rosen Jeffrey M: Dna sequences to target proteins to the mammary gland for efficient secretion.. Baylor College Medicine, August 24, 1988: EP0279582-A2 (47 worldwide citation)

Described is a method of targeting specific genes to the mammary gland which results in the efficient synthesis and secretion of biologically important molecules. Further, there is described as a composition of matter, a transgenic mammal having the ability to reproduce itself and being suitable for ...


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Caskey Charles T, Chamberlain Jeffrey S, Gibbs Richard A L, Rainer Joel E, Nguyen Phi Nga: Multiplex genomic dna amplification for deletion detection.. Baylor College Medicine, April 18, 1990: EP0364255-A2 (39 worldwide citation)

The present invention relates to a method for detecting multiple DNA sequences simultaneously. The method involves amplification of multiple sequences simultaneously by annealing a plurality of paired oligonucleotide primers to single stranded DNA. One member of each pair is complimentary to the sen ...


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Eggers Mitchell D, Hogan Michael E, Beattie Kenneth Loren, Shumaker John, Ehrlich Daniel J, Hollis Mark: Method and apparatus for molecule detection.. Houston Advanced Res Center, Massachusetts Inst Technology, Baylor College Medicine, May 26, 1993: EP0543550-A1 (34 worldwide citation)

A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal ...


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Caskey Charles Thomas, Gibbs Richard Alexander Lloyd: Mutation detection by competitive oligonucleotide priming.. Baylor College Medicine, September 20, 1989: EP0333465-A2 (34 worldwide citation)

The present invention relates to a process for the rapid and simple detection of mutations in DNA and differences between DNA sequences. This competitive oligonucleotide priming system can be used for the detection of any differences between DNA sequences for which a DNA sequence is known. In its ba ...


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Detection of human cancer cells with antibodies to human cancer cell nucleolar antigen(s). Baylor College Medicine, July 22, 1981: GB2067286-A (16 worldwide citation)

Specific nucleolar antigen(s) are found common to a broad range of human malignant tumor specimens and have been isolated, extracted and purified. Antibodies and antisera specific to these nucleolar antigen(s) are harvested from non-human hosts and used for detection of human cancer cells. Disclosed ...


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Thompson Timothy C, Wyllie Michael G, Yang Guang: Use of alpha1-adrenoreceptor antagonists in the manufacture of a medicament for the prevention and treatment of benign prostatic hyperplasia. Pfizer, Baylor College Medicine, October 8, 1997: EP0799619-A2 (13 worldwide citation)

A method for treating or preventing a BPH in a mammal which comprises administering to said mammal an amount of a drug, comprising an alpha 1-adrenoreceptor antagonist or pharmaceutically acceptable acid addition salt thereof, effective for treating or preventing the BPH.


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