1
Sehgal Surendra N, Blazekovic Teodora M, Vezina Claude: Rapamycin and process of preparation. Ayerst McKenna and Harrison, December 30, 1975: US3929992 (345 worldwide citation)

Antibiotic rapamycin is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. Rapamycin has antifungal properties. Methods for its preparation and use are disclosed.


2
Sumanas Rakhit: Acyl derivatives of rapamycin. Ayerst McKenna and Harrison, Arthur E Wilfond, February 23, 1982: US04316885 (225 worldwide citation)

Disclosed are monoacyl and diacyl derivatives of rapamycin, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are useful, inter alia, as antifungal antibiotics.


3
Surendra N Sehgal, Teodora M Blazekovic, Claude Vezina: Rapamycin and process of preparation. Ayerst McKenna and Harrison, November 23, 1976: US03993749 (203 worldwide citation)

Antibiotic rapamycin is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. Rapamycin has antifungal properties. Methods for its preparation and use are disclosed.


4

5
Jehan F Bagli, Tibor Bogri Montreal: Derivatives of 9-oxo-15-hydroxyprostanoic acid, homologs thereof and their preparation. Ayerst McKenna and Harrison Ville St Laurent, Edmund H OBrien, Andrew Kafko, Dwight J Potter, Joseph Marin Weigman, June 20, 1972: US3671570 (15 worldwide citation)

There are disclosed herein derivatives of 9-oxo-15-hydroxy prostanoic acid, lower alkyl esters thereof, and homologs thereof, as well as a process for preparing the above acids, lower alkyl esters thereof, and homologs thereof. The compounds possess hypotensive, antihypertensive, bronchospasmolytic ...


6
Adolf H Philipp, Christopher A Demerson, Leslie G Humber: Pyrroloisoquinoline derivatives. Ayerst McKenna and Harrison, John P Floyd, April 13, 1976: US03950343 (14 worldwide citation)

1,3,4,5-Tetrahydropyrrolo[4,3,2-de]isoquinoline and its N-alkyl derivatives are disclosed. The compounds are antidepressant and antihypertensive agents. Methods for their preparation and use are disclosed.


7
Adolf H Philipp, Ivo L Jirkovsky: 1,4-Dihydro-4-oxo-benzothiopyrano (4,3-b)pyridine-2-carboxylates and derivatives. Ayerst McKenna and Harrison, Arthur E Wilfond, November 29, 1977: US04060619 (13 worldwide citation)

Compounds of formula 1 ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different selected from the group consisting of hydrogen, halogen, nitro, trifluoromethyl, lower alkyl and lower alkoxy, or R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, or R.sup.3 and R.sup.4 together form a ...


8
Demerson Christopher A, Humber Leslie G, Asselin Andre A, Jirkovsky Ivo, Dobson Thomas A: Pyrano-and thiopyranoindole. Ayerst McKenna and Harrison, April 29, 1975: US3880853 (13 worldwide citation)

Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3- ...


9
Jean Marie Ferland, Real Laliberte, Wilbur Lippmann, Thomas A Pugsley: Aryloxy aminobutanols, their preparation and use thereof. Ayerst McKenna and Harrison, Adley F Mandel, January 31, 1978: US04071552 (12 worldwide citation)

Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl th ...


10
Christopher A Demerson, Leslie G Humber, Andre A Asselin, Ivo Jirkovsky, Thomas A Dobson: Pharmaceutical method for using pyrano-and thiopyranoindole derivatives. Ayerst McKenna and Harrison, August 9, 1977: US04041169 (12 worldwide citation)

Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3- ...