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Goutopoulos Andreas, Askew Jr Benny C, Diep Nhut Kiet, Karra Srinivasa, Schwarz Matthias, Yu Henry: Novel arylamino n-heteraryls as mek inhibitors. Laboratoires Serono, Goutopoulos Andreas, Askew Jr Benny C, Diep Nhut Kiet, Karra Srinivasa, Schwarz Matthias, Yu Henry, DAVIS Steven G, November 1, 2007: WO/2007/123939 (10 worldwide citation)

The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed. is the treatment of a hyperproliferative disease in mammals, and phar ...


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Yuan Chester Chenguang, Yang Kevin, Vanderplas Simon, Riahi Babak, Potashman Michele, Patel Vinod F, Nomak Rana, Li Aiwen, Huang Qi, Harmange Jean Christophe, Askew Jr Benny C: Substituted aryl-amine derivatives and methods of use. Amgen, Yuan Chester Chenguang, Yang Kevin, Vanderplas Simon, Riahi Babak, Potashman Michele, Patel Vinod F, Nomak Rana, Li Aiwen, Huang Qi, Harmange Jean Christophe, Askew Jr Benny C, February 2, 2006: WO/2006/012374 (4 worldwide citation)

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-d ...


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Ng Gordon, Li Yue Sheng, Gegg Colin V, Askew Jr Benny C, Storz Thomas, Lu Yuelie, D Amico Derin C: Antagonists of the bradykinin b1 receptor. Amgen, Ng Gordon, Li Yue Sheng, Gegg Colin V, Askew Jr Benny C, Storz Thomas, Lu Yuelie, D Amico Derin C, SHARP Robert L, May 12, 2005: WO/2005/042027

The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides ...


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D Amico Derin C, Askew Jr Benny C: Method of conjugating aminothiol containing molecules to a polymer. Amgen, D Amico Derin C, Askew Jr Benny C, SHARP Robert L, July 27, 2006: WO/2006/079099

The present invention relates to a novel chemical process that provides novel vehicle derivatives that are exceptional 1,2- or 1,3-aminothiol specific reagents for conjugation to unprotected targeted compounds (e.g., polypeptides, peptides, or organic compounds) having or modified to have a 1,2- or ...