1
Pierre Trepagnier, Jenny Freeman, James Mansfield, Derek Brand, Michael J Hopmeier, Nikiforos Kollias: Non-invasive tissue glucose level monitoring. Argose, Ivor R Elrifi, Christina K Stock, Mintz Levin Cohn Ferris Glovsky & Popeo PC, April 13, 2004: US06721582 (321 worldwide citation)

Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.


2
Wei Dong Tian, Pierre Trepagnier: Generation of spatially-averaged excitation-emission map in heterogeneous tissue. Argose, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, July 22, 2003: US06597932 (290 worldwide citation)

An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue s ...


3
Pierre Trepagnier: Asynchronous fluorescence scan. Argose, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, October 28, 2003: US06639668 (275 worldwide citation)

The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention ...


4
Bellott Emile M, Bu Dongsheng, Childs James J, Lambert Christopher R, Nienaber Hubert A, Shi Shirley J, Wang Zhaolin, Workman Jerome J Jr, Zelenchuk Alex R: Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors. Argose, Bellott Emile M, Bu Dongsheng, Childs James J, Lambert Christopher R, Nienaber Hubert A, Shi Shirley J, Wang Zhaolin, Workman Jerome J Jr, Zelenchuk Alex R, ELRIFI Ivor R, July 21, 2005: WO/2005/065241 (12 worldwide citation)

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, adva ...


5
Workman Jerome J, Lambert Christopher R, Coleman Robert L: Non-invasive measurement of analytes. Argose, Workman Jerome J, Lambert Christopher R, Coleman Robert L, ELRIFI Ivor R, May 27, 2004: WO/2004/044557 (6 worldwide citation)

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods fo ...


6
Messerschmidt Robert G, Mansfield James, Brand Derek, Freeman Jenny E, Hopmeier Michael J: Adjunct quantitative system and method for non-invasive measurement of in vivo analytes. Argose, Messerschmidt Robert G, Mansfield James, Brand Derek, Freeman Jenny E, Hopmeier Michael J, ELRIFI Ivor R, February 6, 2003: WO/2003/010510 (2 worldwide citation)

The invention is directed to a method and apparatus for detecting and measuring the concentration of an analyte in a tissue and a patient. Particularly, the invention is directed to methods wherein a spectroscopic measurement is combined with an adjunct spectroscopic or non-spectroscopic measurement ...


7
Messerschmidt Robert G, Childs Jim, Trepagnier Pierre, Mansfield James, Freeman Jenny E, Toy Sean, Chance Britton: Optical coupler for measuring tissue fluorescence. Argose, Messerschmidt Robert G, Childs Jim, Trepagnier Pierre, Mansfield James, Freeman Jenny E, Toy Sean, Chance Britton, REMENICK James, February 6, 2003: WO/2003/010561

The present invention is directed to a device for efficiently optically coupling an area of tissue to a spectroscope. The optical coupler preferably comprises a rigid partial enclosure having an inside wall that reflects electromagnetic radiation, an opening on the enclosure for the passage of light ...


8
Mansfield James: Reduction of spectral site to site variation. Argose, Mansfield James, REMENICK James, May 16, 2002: WO/2002/038043

The invention relates to devices and methods that improve the quality of optic measurements from surfaces such as skin and biological materials. Three methods for reducing spectral site to site variation in fluorescence and/or reflectance signals obtained from a sample surface are: repeated measurem ...


9
Cohen Carl, Hurrell John: Portable non-invasive glucose monitor. Argose, Cohen Carl, Hurrell John, sREMENICK James, March 20, 2003: WO/2003/023356

The invention provides a hand-held glucose monitor and an optical coupler that allows for short-term discontinuous and/or continuous information on dynamic in vivo glucose levels. The device comprises an instrument body (101) which contains a display (102). The device may include an optical coupler ...


10
Apruzzese William, Trepagnier Pierre, Gray Russell, Mansfield James, Lambert Christopher: Layered calibration standard for tissue sampling. Argose, Apruzzese William, Trepagnier Pierre, Gray Russell, Mansfield James, Lambert Christopher, REMENICK James, August 15, 2002: WO/2002/063269

The invention relates to fluorescence calibration devices and methods that can mimic skin and other tissues. A calibration device (100) of the invention comprises at least one scattering layer (110), which is preferably non-fluorescent, and a second layer (120) containing one or more fluorophore (12 ...



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