1
Simon Jonathon Spence, Richard Alexander Grant, Timothy Doyle Peele, William Samuel Hunter, Ashraf F Abdelmoteleb, David Thomas Kneen, Robert Alister Neil, Simon Harris: Systems and methods for processing samples in a closed container, and related devices. Argos Therapeutics, Myers Bigel Sibley & Sajovec P A, October 4, 2011: US08030080 (27 worldwide citation)

A system and method for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or ...


2
Healey Don, Tcherepanova Irina, Adams Melissa, Hinohara Atsushi: Mature dendritic cell compositions and methods for culturing same. Argos Therapeutics, Kirin Beer Kabushiki Kaisha, Healey Don, Tcherepanova Irina, Adams Melissa, Hinohara Atsushi, ARGOS THERAPEUTICS, April 20, 2006: WO/2006/042177 (17 worldwide citation)

This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (DCs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (iDCs) with a first signal comp ...


3
Healey Donald, Tcherepanova Irina, Hinohara Atsushi, Adams Melissa, Debenedette Mark: Mature dendritic cell compositions and methods for culturing same. Argos Therapeutics, Kirin Pharma Kabushiki Kaisha, Healey Donald, Tcherepanova Irina, Hinohara Atsushi, Adams Melissa, Debenedette Mark, ARGOS THERAPEUTICS, October 18, 2007: WO/2007/117682 (11 worldwide citation)

This invention provides novel CD40L polypeptides and nucleic acids, as well as antigen presenting cells and vaccines comprising such CD40L polypeptides and/or nucleic acids, and related methods for preparing the antigen presenting cells and vaccines. The antigen presenting cells and vaccines are use ...


4
Nicolette Charles, Fathman C Garrison, Creusot Remi: Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection. Argos Therapeutics, The Board Of Trustees Of The Leland Stanford Junior University, Nicolette Charles, Fathman C Garrison, Creusot Remi, ARGOS THERAPEUTICS, September 3, 2009: WO/2009/108341 (10 worldwide citation)

A method is provided for treating or preventing an undesired immune response in a patient, comprising: administering to said patient, cells that transiently express, and/or that are transfected with mRNA encoding, one or more polypeptides selected from the group consisting of an IL-4 receptor agonis ...


5
Simon Jonathon Spence, Richard Alexander Grant, Timothy Doyle Peele, William Samuel Hunter, Ashraf F Abdelmoteleb, David Thomas Kneen, Robert Alister Neil, Simon Harris: Methods for processing samples in a closed container. Argos Therapeutics, Myers Bigel Sibley & Sajovec P A, July 3, 2012: US08211701 (8 worldwide citation)

A system and method for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or ...


6
MONESMITH Tamara Tatroe, CAPRIHAN Arjun V, RYAN Christopher Thomas, GRANT Richard A, FITZPATRICK Ian S, LEIGH LANCASTER Christopher John: [fr] CUVES DE CENTRIFUGEUR ADAPTÉES AU TRAITEMENT DE CELLULES VIVANTES ET SYSTÈMES ET PROCÉDÉS ASSOCIÉS, [en] CENTRIFUGE VESSELS SUITABLE FOR LIVE CELL PROCESSING AND ASSOCIATED SYSTEMS AND METHODS. ARGOS THERAPEUTICS, MYERS BIGEL SIBLEY & SAJOVEC PA, August 8, 2013: WO/2013/116041 (7 worldwide citation)

[en] Centrifuge vessels suitable for live cell processing include a bowl with a cap, and a tube inside the bowl extending between the cap and a lower portion of the bowl. The bottom of the bowl can have a closed annular ring surrounding a center mound. The vessels can be particularly suitable for pr ...


7
Schuler Gerold, Dörrie Jan, Schaft Niels: Methods for generating antigen-specific effector t cells. Argos Therapeutics, Schuler Gerold, Dörrie Jan, Schaft Niels, HELBING Jörg, June 14, 2007: WO/2007/065957 (6 worldwide citation)

The invention relates to T cells transiently transfected with RNA, especially RNA encoding a T cell receptor and/or FoxP3, and to methods of transfecting T cells with RNA by electroporation. Compositions of the invention include an effector T cell transiently transfected with RNA encoding a T cell r ...


8
Nicolette Charles, Tcherepanova Irina, Harris Jason, Healey Donald: Strain independent amplification of pathogens and vaccines thereto. Argos Therapeutics, Kirin Beer Kabushiki Kaisha, Nicolette Charles, Tcherepanova Irina, Harris Jason, Healey Donald, sARGOS THERAPEUTICS, March 23, 2006: WO/2006/031870 (5 worldwide citation)

This in invention relates to methods for the nucleic acid amplification of multiple variants (strains) of any pathogen present in a sample, and preferably in a sample from a pathogen infected individual. In preferred embodiments, the pathogen is a retrovirus, such as HIV. The amplified pathogen nucl ...


9
Ralph M Steinman, Nina Bhardwaj, Gerold Schuler: Methods and compositions for obtaining mature dendritic cells. The Rockefeller University, Argos Therapeutics, Elaine Sale, Leigh Thorne, April 3, 2007: US07198948 (4 worldwide citation)

We describe an improved method for generating sizable numbers of mature dendritic cells from nonproliferating progenitors in human blood. The first step or “priming” phase is a culture of T cell depleted mononuclear cells in medium supplemented with GM-CSF and IL-4 to produce immature dendritic cell ...


10
Gerold Schuler, Beatrice Schuler Thurner: Method for producing ready to use, antigen-loaded or unloaded, cryoconserved mature dendritic cells. Argos Therapeutics, Elaine Sale, Leigh Thorne, August 7, 2012: US08236562 (4 worldwide citation)

The invention relates to a method for producing ready to use, antigen loaded or unloaded, cryoconserved mature dendritic cells especially for the production of a vaccine containing said dendritic cells, wherein immature dendritic cells are cultivated in the presence of suitable maturation stimuli an ...