1
Howard R Levin, Mark Gelfand: Renal nerve stimulation method and apparatus for treatment of patients. Ardian, Perkins Coie, January 9, 2007: US07162303 (421 worldwide citation)

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. A ...


2
Mark Gelfand, Howard R Levin: Methods and devices for renal nerve blocking. Ardian, Perkins Coie, December 20, 2005: US06978174 (317 worldwide citation)

A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump eluting implant for targeted delivery of a nerve-blocking age ...


3
Mark Deem, Hanson Gifford III, Denise Demarais, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R Levin: Methods and apparatus for renal neuromodulation. Ardian, Perkins Coie, January 26, 2010: US07653438 (311 worldwide citation)

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the ...


4
Denise Demarais, Nicolas Zadno, Benjamin J Clark, Erik Thai, Howard R Levin, Mark Gelfand: Methods and apparatus for thermally-induced renal neuromodulation. Ardian, Perkins Coie, November 10, 2009: US07617005 (296 worldwide citation)

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or ...


5
Denise Demarais, Benjamin J Clark, Nicolas Zadno, Erik Thai, Hanson Gifford III: Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach. Ardian, Perkins Coie, November 17, 2009: US07620451 (279 worldwide citation)

Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other c ...


6
Denise Demarais, Nicolas Zadno, Benjamin J Clark, Erik Thai, Howard R Levin, Mark Gelfand: Methods and apparatus for thermally-induced renal neuromodulation. Ardian, Perkins Coie, May 18, 2010: US07717948 (274 worldwide citation)

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or ...


7
Howard R Levin, Mark Gelfand: Renal nerve stimulation method and apparatus for treatment of patients. Ardian, Perkins Coie, January 12, 2010: US07647115 (247 worldwide citation)

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. A ...


8
Denise Demarais, Nicolas Zadno, Benjamin J Clark, Erik Thai: Methods and apparatus for intravascularly-induced neuromodulation. Ardian, Perkins Coie, July 13, 2010: US07756583 (239 worldwide citation)

Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target n ...


9
Denise Demarals, Hanson Gifford III, Mark Deem, Howard R Levin, Mark Gelfand, Nicolas Zadno: Methods and apparatus for monopolar renal neuromodulation. Ardian, Perkins Coie, March 6, 2012: US08131371 (222 worldwide citation)

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or bl ...


10
Denise Demarais, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods for catheter-based renal denervation. Ardian, Perkins Coie, April 3, 2012: US08150520 (207 worldwide citation)

Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or e ...



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