1
Ubaldo Conte, Lauretta Maggi, Paolo Giunchedi: Multilayered controlled-release oral solid pharmaceutical forms. APR Applied Pharma Research, Nixon & Vanderhye, October 28, 1997: US05681583 (66 worldwide citation)

Multilayered controlled-release solid pharmaceutical composition in tablet form suitable for oral administration comprising at least two layers containing active material in association with excipients and additives. One layer of the tablet releases a portion of the drug quickly while the other laye ...


2
Alberto Reiner, Alessandro Seneci: Pharmaceutical compositions based on chewing gum and a method for the preparation thereof. APR Applied Pharma Research, Nixon & Vanderhye, January 27, 1998: US05711961 (52 worldwide citation)

Chewing gum tablets and their methods of preparation are disclosed. The gum tablets contain a mixture of chewing gum base and sugary microgranules with an additive agent and an active ingredient adsorbed onto their surface. A lacquer coating on the tablet contains cellulose and polyethlene glycols. ...


3
Reiner Giorgio, Reiner Alberto, Meyer Andreas: Diclofenac formulations and methods of use. Apr Applied Pharma Research, Reiner Giorgio, Reiner Alberto, Meyer Andreas, LEISSLER GERSTL Gabriele, December 21, 2006: WO/2006/133954 (15 worldwide citation)

Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and ...


4
Maichle William R, Whatley Carl L, Reiner Giorgio, Reiner Alberto: Acute pain medications based on fast acting diclofenac-opioid combinations. Proethic Pharmaceuticals, Apr Applied Pharma Research, Maichle William R, Whatley Carl L, Reiner Giorgio, Reiner Alberto, SULLIVAN Clark G, November 15, 2007: WO/2007/130507 (9 worldwide citation)

Provided are combined oral dosage forms for the treatment of pain, particularly combined dosage forms that are specially formulated for rapid bioavailability, and that contain diclofenac potassium and an opioid selected from hydrocodone, oxycodone, fentanyl and tramadol.


5
Norman D Schellenger, William R Maichle, Carl L Whatley Jr, Giorgio Reiner, Alberto Reiner: Blister packaging for acute pain regimens. APR Applied Pharma Research, Arnall Golden Gregory, Clark G Sullivan, May 10, 2011: US07939561 (7 worldwide citation)

Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable tablet dosage forms. Also provided is packaging that discourages the use of rapidly bioavailable acute pain medications for ...


6
Giuseppe Vecchi: Process for the preparation of substituted tetrahydrofolico derivatives in the [6(R,S)(-)] forms and of their active [6(S)(-)] N.sup.5 diastereoisomers in form of alkali and alkaline earth metal salts. APR Applied Pharma Research, Nixon & Vanderhye, September 27, 1994: US05350850 (4 worldwide citation)

Process for the preparation of the optically active [6(S)(-)]N.sup.5 alkaline earth metal salts of methyltetrahydrofolic acid and formyltetrahydrofolic acid wherein an aqueous solution of folic acid is hydrogenated with a high stoichiometric excess of sodium borohydride followed by treating the reac ...


7
Leichs Christian, Breitenbach Armin, Lehrke Ingo, Galfetti Paolo: Non-mucoadhesive film dosage forms. Labtec Gesellschaft Für Technologische Forschung Und Entwicklung Mbh, Apr Applied Pharma Research, Leichs Christian, Breitenbach Armin, Lehrke Ingo, Galfetti Paolo, LEISSLER GERSTL Gabriele, April 10, 2008: WO/2008/040534 (4 worldwide citation)

Orally disintegrating film dosage forms for delivering active pharmaceutical agents, methods of formulating the dosage forms to retard absorption through the oral mucosa, and methods of using the dosage forms for the treatment of various medical conditions are provided.


8
Guiseppe Vecchi: Process for the separation of folinic acids. APR Applied Pharma Research, Nixon & Vanderhye, February 21, 1995: US05391738 (3 worldwide citation)

The treatment of racemic calcium folinate with a sodium salt of ethylendiaminotetraacetic acid and, preferably, calcium cloride determines the separation of a precipitate, whose mother liquors result enriched in a calcium salt of the levofolinic acid, purifiable through repeated crystallizations.


9
Giorgio Reiner, Alberto Reiner, Andreas Meyer: Diclofenac formulations and methods of use. APR Applied Pharma Research, Clark G Sullivan, Arnall Golden Gregory, July 20, 2010: US07759394 (3 worldwide citation)

Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and ...


10
Giorgio Reiner, Alberto Reiner, Andreas Meyer: Diclofenac formulations and methods of use. APR Applied Pharma Research, Clark G Sullivan, Arnall Golden Gregory, January 17, 2012: US08097651 (2 worldwide citation)

Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and ...