1
Ilya Ravkin: Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images. Applied Imaging, Townsend and Townsend and Crew, July 10, 2001: US06259807 (88 worldwide citation)

Detection of fetal nucleated red blood cells (NRBCs) is achieved by employing a combination of brightfield and fluorescence images of nuclear and cytoplasmic markers. The brightfield and fluorescence images are all obtained with a single multibandpass dichroic mirror. The objects in the sample are s ...


2
Alexander M Saunders, Michael A M Zarowitz, Patricia J Baldwin: Method for separating rare cells from a population of cells. Applied Imaging, Townsend and Townsend Khourie and Crew, July 11, 1995: US05432054 (86 worldwide citation)

A method for isolating and enriching rare cells, including fetal nucleated erythrocytes from a peripheral blood sample is described. The method includes two centrifugation steps, the first a bulk separation step to enrich erythrocytes from other blood components. The second centrifugation comprises ...


3
Ilya Ravkin: Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images. Applied Imaging, Townsend and Townsend and Crew, January 2, 2001: US06169816 (76 worldwide citation)

Detection of fetal nucleated red blood cells (NRBCs) is achieved by employing a combination of brightfield and fluorescence images of nuclear and cytoplasmic markers. The brightfield and fluorescence images are all obtained with a single multi-bandpass dichroic mirror. The objects in the sample are ...


4
Jacques Ginestet: Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration. Applied Imaging, Townsend and Townsend and Crew, March 9, 1999: US05880473 (66 worldwide citation)

Techniques for acquiring and analyzing M-FISH images in a manner that allows for proper image registration; and techniques for combining a plurality of registered images to provide labeled images. Epi-illumination embodiments use multiple filter cubes for different subsets of the entire set of desir ...


5
Hal Rutherford, Floyd Taub: Method and apparatus for generating quantifiable video displays. Applied Imaging Corporation, Skjerven Morrill MacPherson Franklin & Friel, November 26, 1991: US05068909 (54 worldwide citation)

An apparatus and method for removing background noise and high frequency noise from an image by comparing each pixel in the image with neighboring pixels defining a variably shaped and sized kernel. The size and shape of the kernel are optimized for the particular characteristics of the data to be a ...


6
Jacques Ginestet: Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration. Applied Imaging, Townsend and Townsend and Crew, May 1, 2001: US06225636 (49 worldwide citation)

Techniques for acquiring and analyzing M-FISH images in a manner that allows for proper image registration; and techniques for combining a plurality of registered images to provide labeled images. Epi-illumination embodiments use multiple filter cubes for different subsets of the entire set of desir ...


7
Alexander Michael Saunders: Method for analyzing DNA from a rare cell in a cell population. Applied Imaging Corporation, Townsend and Townsend and Crew, July 11, 2000: US06087134 (49 worldwide citation)

Methods are provided for analyzing DNA of a rare cell in a cell population. In one embodiment, the method involves covering a cell monolayer with a photosensitive material. By illuminating the area over a cell of interest, the material is solidified, permitting manipulation of the underlying cell an ...


8
Mitchell Golbus: Use of anti-embryonic epsilon hemoglobin antibodies to identify fetal cells. Applied Imaging Corporation, Townsend & Townsend & Crew, October 5, 1999: US05962234 (47 worldwide citation)

An in vitro method of identifying or isolating fetal cells from a blood sample is described. Fetal nucleated erythrocytes or erythroblasts are identified by using an antibody or antibody fragment specific for embryonic hemoglobin or an embryonic hemoglobin chain. Once the fetal cells are identified, ...


9
Alexander M Saunders, Patricia J Baldwin, Michael A M Zarowitz: Centrifuge tube and adaptor. Applied Imaging, Townsend and Townsend Khourie and Crew, June 6, 1995: US05422018 (45 worldwide citation)

A centrifuge tube and adaptor apparatus is provided which facilitates separation of biological materials and permits easy extraction of a fraction after centrifugation. The tube is a deformable tube with a wide upper chamber and a narrowed lower portion. The tube is supported within the centrifuge r ...


10
Mitchell Golbus: Use of anti-embryonic hemoglobin antibodies to identify fetal cells. Applied Imaging, Townsend and Townsend and Crew, March 24, 1998: US05731156 (45 worldwide citation)

An in vitro method of identifying or isolating fetal cells from a blood sample is described. Fetal nucleated erythrocytes or erythroblasts are identified by using an antibody or antibody fragment specific for embryonic hemoglobin or an embryonic hemoglobin chain. Once the fetal cells are identified, ...