1
J Craig Venter, Jinghui N Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage: Polymorphisms in known genes associated with human disease, methods of detection and uses thereof. Applera Corporation, Justin D Karjala, Celera, November 2, 2004: US06812339 (278 worldwide citation)

The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to human disease. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant human disease associated protein. The present invention provides ...


2
Timothy W Woudenberg, Michael Albin, Reid B Kowallis, Yefim Raysberg, Robert P Ragusa, Emily S Winn Deen: Device and method for multiple analyte detection. Applera Corporation, Kilyk & Bowersox P L L C, November 30, 2004: US06825047 (170 worldwide citation)

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid ...


3
John C Gerdes, Jeffery M Marmaro, Jeffrey T Ives, Christopher A Roehl: Nucleic acid archiving. Applera Corporation, Hogan & Hartson L, August 8, 2006: US07087387 (102 worldwide citation)

This invention provides a kit comprising a substrate having a surface coated with a solid phase matrix for nucleic acid manipulation. The solid phase matrix exhibits sufficient hydrophilicity and electropositivity to tightly bind the nucleic acids in a sample. The manipulations include nucleic acid ...


4
Timothy W Woudenberg, Michael Albin, Reid B Kowallis, Yefim Raysberg, Robert P Ragusa, Emily S Winn Deen: Nucleic acid analysis device. Applera Corporation, Kilyk & Bowersox P L L C, June 26, 2007: US07235406 (85 worldwide citation)

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid ...


5
Timothy M Woudenberg, Reid B Kowallis: High density electrophoresis device and method. Applera Corporation, Vincent M Powers, December 9, 2003: US06660147 (69 worldwide citation)

The present invention provides, in one aspect, an apparatus for electrophoretic separation of analytes. In one aspect, the apparatus comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of electrophoretic channels in fluid communication with, and emanating subst ...


6
Michael R Gambini, John G Atwood, Eugene F Young, Edward J Lakatos, Anthony L Cerrone: Instrument for monitoring polymerase chain reaction of DNA. Applera Corporation, Kilyk & Bowersox P L L C, November 16, 2004: US06818437 (63 worldwide citation)

An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emissio ...


7
Michael Egholm, Caifu Chen: Template-dependent ligation with PNA-DNA chimeric probes. Applera Corporation, Alex Andrus, October 2, 2001: US06297016 (60 worldwide citation)

The invention provides methods, kits, and compositions for ligation of PNA-DNA chimeric probes and oligonucleotides when they are hybridized adjacently to template nucleic acids using ligases and ligation reagents. Structural requirements of the chimeras for ligation include 5 to 15 contiguous PNA m ...


8
Mckernan Kevin, Blanchard Alan, Costa Gina: Reagents, methods, and libraries for gel-free bead-based sequencing. Applera Corporation, Mckernan Kevin, Blanchard Alan, Costa Gina, BASTIAN Michael J, October 25, 2007: WO/2007/121489 (58 worldwide citation)

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension p ...


9
Zbigniew T Bryning, John Shigeura: Microfluidic devices, methods, and systems. Applera Corporation, Kilyk & Bowersox P L L C, April 3, 2007: US07198759 (57 worldwide citation)

Microfluidic assemblies, systems, and methods are provided for manipulating fluid samples. Assemblies include an elastically deformable cover layer and a less elastically deformable substrate. The methods include deforming the substrate through the cover layer so that when the cover layer rebounds a ...


10
Tan Lim Hi, Ngui Jew Kwee, Shin Hou Siu, Soh Ui Leng, Kee Yang Hooi, Khoo Hock Lai, Reed Mark T, Lau Ching Ong, Heimberg Wolfgang: Device for carrying out chemical or biological reactions. Applera Corporation, Tan Lim Hi, Ngui Jew Kwee, Shin Hou Siu, Soh Ui Leng, Kee Yang Hooi, Khoo Hock Lai, Reed Mark T, Lau Ching Ong, Heimberg Wolfgang, HSIEH Timothy M, March 13, 2008: WO/2008/030914 (57 worldwide citation)

The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive ...