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William L Hunter, David M Gravett, Philip M Toleikis, Arpita Maiti, Pierre E Signore, Richard T Liggins, Dechi Guan: Medical implants and fibrosis-inducing agents. Angiotech International, Seed IP Law Group PLLC, January 23, 2007: US07166570 (230 worldwide citation)

Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.


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William L Hunter, Philip M Toleikis, David M Gravett, Rui Avelar, Dechi Guan: Compositions and methods for treating diverticular disease. Angiotech International, Seed IP Law Group PLLC, July 10, 2007: US07241736 (105 worldwide citation)

Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of these agents are provided for use in ...


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Avelar Rui, Liggins Richard T, Toleikis Philip M, Loss Troy A E, Gravett David M, Maiti Arpita: Compositions and methods for treating contracture. Angiotech International, Avelar Rui, Liggins Richard T, Toleikis Philip M, Loss Troy A E, Gravett David M, Maiti Arpita, LIN Qing, August 18, 2005: WO/2005/074913 (72 worldwide citation)

A method for treating contracture is provided that includes administering to a patient in need thereof a composition that includes a therapeutic agent effective in treating contracture. Compositions, devices, and kits for use in treating contracture are also described.


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Hunter William L, Toleikis Philip M, Gravett David M, Maiti Arpita, Liggins Richard T, Takacs Cox Aniko, Avelar Rui, Signore Pierre E, Loss Troy A E, Hutchinson Anne, Mcdonald Jones Gaye, Lakhani Fara: Anti-scarring agents, therapeutic compositions, and use thereof. Angiotech International, Hunter William L, Toleikis Philip M, Gravett David M, Maiti Arpita, Liggins Richard T, Takacs Cox Aniko, Avelar Rui, Signore Pierre E, Loss Troy A E, Hutchinson Anne, Mcdonald Jones Gaye, Lakhani Fara, LIN Qing, December 21, 2006: WO/2006/135479 (53 worldwide citation)

The present invention provides devices or implants that comprise anti-scarring agents, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that ...


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Gravett David M, Toleikis Philip M, Guan Dechi, Signore Pierre E, Spencer Thomas S, Hunter William L, Wang Kaiyue: Perivascular wraps. Angiotech International, Gravett David M, Toleikis Philip M, Guan Dechi, Signore Pierre E, Spencer Thomas S, Hunter William L, Wang Kaiyue, PEPE Jeffrey C, April 8, 2004: WO/2004/028583 (42 worldwide citation)

The present invention provides compositions, devices, and methods for maintaining or improving the integrity of body passageways following surgery, such as at a graft site, or injury. Delivery devices including one or more therapeutic agents and a mesh are described. Representative examples of thera ...


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Liggins Richard T, Takacs Cox Aniko, Gravett David M, Guan Dechi, Loss Troy A E, Liu Muxin: Block copolymer compositions and uses thereof. Angiotech International, Angiotech Pharmaceuticals Us, Liggins Richard T, Takacs Cox Aniko, Gravett David M, Guan Dechi, Loss Troy A E, Liu Muxin, HAN Hai, February 15, 2007: WO/2007/019439 (24 worldwide citation)

The present invention describes compositions, devices, and methods for the production, use and administration of the composition having a non-thermoreversible block copolymer composition.


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Liggins Richard T, Toleikis Philip M, Guan Dechi: Microparticles with high loadings of a bioactive agent. Angiotech International, Liggins Richard T, Toleikis Philip M, Guan Dechi, LIN Qing, January 5, 2006: WO/2006/002365 (24 worldwide citation)

The present invention discloses compositions, devices and methods for the production, use and administration of compositions that comprise microparticles that are loaded with a drug at a concentration of greater than 50% (weight drug/weight microparticle).


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William L Hunter, David M Gravett, Philip M Toleikis, Richard T Liggins, Troy A E Loss: Compositions and methods for coating medical implants. Angiotech International, SEED IP Law Group PLLC, November 20, 2012: US08313760 (17 worldwide citation)

Medical implants are provided which release a fluoropyrimidine or an analog thereof, thereby inhibiting or reducing the incidence of infection associated with the implant.