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Blatt Lawrence M, Wenglowsky Steven M, Andrews Steven W, Condroski Kevin R, Jiang Yutong, Kennedy April L, Doherty George A, Josey John A, Stengel Peter J, Woodard Benjamin T, Madduru Machender R: Macrocyclic compounds as inhibitors of viral replication. Intermune, Blatt Lawrence M, Wenglowsky Steven M, Andrews Steven W, Condroski Kevin R, Jiang Yutong, Kennedy April L, Doherty George A, Josey John A, Stengel Peter J, Woodard Benjamin T, Madduru Machender R, MALLON Joseph J, October 13, 2005: WO/2005/095403 (110 worldwide citation)

The embodiments provide macrocylic compounds, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of tre ...


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Blatt Lawrence M, Seiwert Scott, Beigelman Leonid, Kercher Timothy, Kennedy April L, Andrews Steven W: Novel inhibitors of hepatitis c virus replication. Intermune, Array Biopharma, Blatt Lawrence M, Seiwert Scott, Beigelman Leonid, Kercher Timothy, Kennedy April L, Andrews Steven W, MALLON Joseph J, January 10, 2008: WO/2008/005511 (58 worldwide citation)

The embodiments provide compounds of the general Formula (I), as well as compositions, including pharmaceutical compositions, comprising a, subject compound. The embodiments provide compounds of the general Formula (II), as well as compositions, including pharmaceutical compositions, comprising a su ...


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Blatt Lawrence M, Pan Lin, Seiwert Scott, Andrews Steven W, Martin Pierre, Schumacher Andreas, Beigelman Leonid, Liu Jyanwei, Condroski Kevin, Jiang Yutong, Kaus Robert, Kennedy April, Kercher Timothy, Lyon Michael, Wang bin: Novel macrocyclic inhibitors of hepatitis c virus replication. Intermune, Array Biopharma, Blatt Lawrence M, Pan Lin, Seiwert Scott, Andrews Steven W, Martin Pierre, Schumacher Andreas, Beigelman Leonid, Liu Jyanwei, Condroski Kevin, Jiang Yutong, Kaus Robert, Kennedy April, Kercher Timothy, Lyon Michael, Wang bin, MALLON Joseph J, November 13, 2008: WO/2008/137779 (56 worldwide citation)

The embodiments provide macrocyclic compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treatin ...


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Andrews Steven W, Seiwert Scott, Beigelman Leonid, Blatt Lawrence, Buckman Brad: Novel peptide inhibitors of hepatitis c virus replication. Intermune, Array Biopharma, Andrews Steven W, Seiwert Scott, Beigelman Leonid, Blatt Lawrence, Buckman Brad, HART Daniel, November 20, 2008: WO/2008/141227 (54 worldwide citation)

The embodiments provide compounds of the general Formula (I), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula (II), as well as compositions, including pharmaceutical compositions, comprising a sub ...


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Inaba Takashi, Haas Julia, Shiozaki Makoto, Littman Nicole M, Yasue Katsutaka, Andrews Steven W, Sakai Atushi, Fryer Andrew M, Matsuo Takafumi, Laird Ellen R, Suma Akira, Shinozaki Yuichi, Hori Yoshikazu, Imai Hiroto, Negoro Tamotsu: Cyclopropane compounds and pharmaceutical use thereof. Japan Tobacco, Inaba Takashi, Haas Julia, Shiozaki Makoto, Littman Nicole M, Yasue Katsutaka, Andrews Steven W, Sakai Atushi, Fryer Andrew M, Matsuo Takafumi, Laird Ellen R, Suma Akira, Shinozaki Yuichi, Hori Yoshikazu, Imai Hiroto, Negoro Tamotsu, GARRETT Arthur S, June 30, 2005: WO/2005/058884 (26 worldwide citation)

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is - (CH2) m-X- (CH2)n-A1 et ...


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Fryer Andrew M, Shiozaki Makoto, Littmann Nicole M, Inaba Takashi, Andrews Steven W, Yasue Katsutaka, Laird Ellen R, Yokota Masahiro, Haas Julia, Imai Hiroto, Maeda Katsuya, Shinozaki Yuichi, Hori Yoshikazu: N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof. Japan Tobacco, Fryer Andrew M, Shiozaki Makoto, Littmann Nicole M, Inaba Takashi, Andrews Steven W, Yasue Katsutaka, Laird Ellen R, Yokota Masahiro, Haas Julia, Imai Hiroto, Maeda Katsuya, Shinozaki Yuichi, Hori Yoshikazu, GARRETT Arthur S, June 30, 2005: WO/2005/058808 (21 worldwide citation)

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) : wherein R ...


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Beigelman Leonid, Andrews Steven W, Condroski Kevin R, Gunawaradana Indrani, Haas Julia: Inhibitors of viral replication. Intermune, Beigelman Leonid, Andrews Steven W, Condroski Kevin R, Gunawaradana Indrani, Haas Julia, MALLON Joseph J, April 26, 2007: WO/2007/047146 (5 worldwide citation)

The embodiments provide compounds of the general Formulas I-IV, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver ...