1
Theeuwes Felix, Higuchi Takeru: Osmatic dispensing device for releasing beneficial agent. Alza Corporation, Sabatine Paul L, Mandell Edward L, Benz William H, November 5, 1974: US3845770 (1438 worldwide citation)

A wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the composition is disclosed. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in the fluid and exhibits ...


2
Theeuwes Felix, Higuchi Takeru: Osmotic dispensing device with maximum and minimum sizes for the passageway. Alza Corporation, Sabatine Paul L, Mandell Edward L, Ciotti Thomas E, November 4, 1975: US3916899 (1229 worldwide citation)

A device is disclosed comprised of a wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the compostion. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in th ...


3
Richard Cortese, Felix Theeuwes: Osmotic device with hydrogel driving member. ALZA Corporation, Paul L Sabatine, Edward L Mandell, May 4, 1982: US04327725 (891 worldwide citation)

An osmotic device is disclosed comprising a semipermeable wall surrounding a compartment housing an agent that is insoluble to very soluble in aqueous and biological fluids, and a layer of a fluid swellable, hydrogel. A passageway in the wall connects the agent with the exterior of the device.


4
Zaffaroni Alejandro: Bandage for administering drugs. ALZA Corporation, August 10, 1971: US3598123 (765 worldwide citation)

Bandage for use in the continuous administration of drugs by absorption comprising a backing member bearing a pressure-sensitive adhesive layer on one surface thereof. Distributed throughout the pressure-sensitive adhesive are microcapsules comprised of a systemically active drug encapsulated with a ...


5
Peter E Daddona, Gregory T Fieldson, Avtar S Nat, Wei Qi Lin: Minimally invasive detecting device. Alza Corporation, D Byron Miller, Steve F Stone, July 18, 2000: US06091975 (707 worldwide citation)

An agent detecting device comprising a plate (6) having a plurality of microprotrusions (4) for piercing the skin of a patient. Each of the microprotrusions (4) having an electrode (14, 16 and 18) thereon for detecting the presence of an agent in the patient's interstitial fluid.


6
Felix Theeuwes, Atul D Ayer: Osmotic system having laminar arrangement for programming delivery of active agent. Alza Corporation, Paul L Sabatine, Edward L Mandell, Thomas E Ciotti, February 22, 1977: US04008719 (601 worldwide citation)

An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a la ...


7
Michel J N Cormier, Felix T Theeuwes: Device and method for enchancing transdermal sampling. Alza Corporation, Owen J Bates, D Byron Miller, Steven F Stone, April 17, 2001: US06219574 (579 worldwide citation)

A percutaneous agent sampling device and method are provided. The device comprises a collector and a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent.


8
James E Brown, Wouter E Roorda: Directional drug delivery stent and method of use. Alza Corporation, Burns Doane Swecker & Mathis L, June 6, 2000: US06071305 (460 worldwide citation)

The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through d ...


9
Felix Theeuwes: Microporous-semipermeable laminated osmotic system. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, March 17, 1981: US04256108 (436 worldwide citation)

An osmotic therapeutic system for delivering a drug is disclosed. The system comprises a drug delivery module which module comprises a rate controlling laminated wall surrounding a reservoir and has a portal for delivering drug from the system. The laminated wall comprises a semipermeable lamina in ...


10
Felix Theeuwes, Richard J Saunders, Wayne S Mefford: Process for forming outlet passageways in pills using a laser. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, May 9, 1978: US04088864 (412 worldwide citation)

A high speed process and apparatus are disclosed for forming outlet passageways of accurate, predetermined size in the walls of pills which dispense their contents by osmotically pumping said contents out said outlet passageways. The pills are moved in succession by an indexer past a passageway form ...



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