Egidio Marchi, Lauretta Montecchi: Imidazo-rifamycin derivatives with antibacterial utility. Alfa Farmaceutici S p A, Bucknam and Archer, July 27, 1982: US04341785 (66 worldwide citation)

New rifamicyn derivatives of the following general formula ##STR1## wherein: A may be the structure ##STR2## --x-- is a chemical bond or nil; R is hydrogen or acetyl

Vincenzo Cannata, Gian F Tamagnone: Process for the synthesis of pyrido-imidazo rifamycins. ALFA Farmaceutici S p a, Bucknam and Archer, December 10, 1985: US04557866 (53 worldwide citation)

A new process for the synthesis of pyrido-imidazo-rifamycins of formula ##STR1## wherein R is hydrogen or acetyl, R.sub.1 and R.sub.2 independently represent hydrogen, (C.sub.1-4)-alkyl, benzyloxy, mono- or di-(C.sub.1-3)-alkylamino-(C.sub.1-4)-alkyl, (C.sub.1-3)-alkoxy-(C.sub.1-4)-alkyl, hydroxymet ...


Valerio Borzatta, Manlio Cristofori, Angelo Brazzi: Salified anionic resin for cholesterol and lipid lowering. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, July 20, 1982: US04340585 (33 worldwide citation)

A non-toxic anionic resin selected from resins having a polymeric reticulated skeleton of styrenic or acrylic type, inert to the digestive enzymes, having a molecular weight higher than 1000 and containing ionizable amino groups, resins having a cellulosic reticulated skeleton modified by the introd ...

Rotini Leone Gabriele, Marchi Egidio: New pharmaceutical formulations with programmed release containing antiphlogistics.. Alfa Farmaceutici, February 3, 1988: EP0255002-A1 (28 worldwide citation)

New galenic formulations with programmed release, to be administered by oral route, containing as the active ingredient a compound endowed with antiphlogistic, analgesic and antipyretic activity like, for instance, an arylacetic or an arylpropionic acid and the pharmaceutically acceptable salts ther ...

Egidio Marchi, Lauretta Montecchi: Process for the preparation of 3 iodo- and 3 bromorifamycin s. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, December 18, 1979: US04179438 (11 worldwide citation)

A process is disclosed for the preparation of 3 iodo-3 bromorifamycin S which consists in reacting rifamycin S with at least 2 equivalents of the corresponding halogen in the presence of at least one mole of pyridine for each equivalent of halogen. The reaction is carried out in inert, polar, hydrof ...

Egidio Marchi, Lauretta Montecchi: Rifamycin derivatives and process for their preparation. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, April 29, 1980: US04200574 (10 worldwide citation)

8-amino and 8-iminorifamycins S and SV are prepared by reacting 8-methoxyrifamycin S with ammonia in an inert polar and hydrophillic solvent, converting the 8-iminorifamycin S into 8 aminorifamycin S by reaction with ammonium hydroxide in a mixture of chloroform and methanol and, if so desired, redu ...

Manlio Cristofori, Valerio Borzatta, Mauro Morotti: Nicotinates of alkanediols having hypolipidaemic activity and pharmaceutical compositions containing them. Alfa Farmaceutici S p A, Bucknam and Archer, June 12, 1984: US04454145 (9 worldwide citation)

New compounds of general formula ##STR1## and salts therewith of pharmaceutically acceptable acids, wherein R and R.sub.1 independently represent a hydrogen atom or a straight or branched alkyl group having from 1 to 5 carbon atoms, and n is an integer from 4 to 12; and of general formula ##STR2## w ...

Vincenzo Cannata, Graziano Zagnoni: Process for the optical resolution of mixtures of D- and L-2-(6-methoxy-2-naphthyl)-propionic acids. Alfa Farmaceutici S p A, Bucknam and Archer, August 16, 1983: US04399284 (5 worldwide citation)

A new process for the optical resolution of mixtures of d- and 1-2-(6-methoxy-2-naphthyl)-propionic acids, which comprises preparing a solution of a mixture of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids and an optically active organic base in a predetermined organic solvent, slowly cooling the ...

Valerio Borzatta: Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing pharmacological activity. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, January 20, 1981: US04246201 (5 worldwide citation)

Compound of formula: ##STR1## wherein R represents hydrogen or an alkyl group having from 1 to 4 carbon atoms; R', R", R'" and R"", equal or different from each other represent hydrogen atoms or OH groups, with the limitation that when R', R", R'" and R"" are all hydrogen atoms R cannot be an hydrog ...