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Egidio Marchi, Lauretta Montecchi: Imidazo-rifamycin derivatives with antibacterial utility. Alfa Farmaceutici S p A, Bucknam and Archer, July 27, 1982: US04341785 (66 worldwide citation)

New rifamicyn derivatives of the following general formula ##STR1## wherein: A may be the structure ##STR2## --x-- is a chemical bond or nil; R is hydrogen or acetyl


2
Vincenzo Cannata, Gian F Tamagnone: Process for the synthesis of pyrido-imidazo rifamycins. ALFA Farmaceutici S p a, Bucknam and Archer, December 10, 1985: US04557866 (53 worldwide citation)

A new process for the synthesis of pyrido-imidazo-rifamycins of formula ##STR1## wherein R is hydrogen or acetyl, R.sub.1 and R.sub.2 independently represent hydrogen, (C.sub.1-4)-alkyl, benzyloxy, mono- or di-(C.sub.1-3)-alkylamino-(C.sub.1-4)-alkyl, (C.sub.1-3)-alkoxy-(C.sub.1-4)-alkyl, hydroxymet ...


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Valerio Borzatta, Manlio Cristofori, Angelo Brazzi: Salified anionic resin for cholesterol and lipid lowering. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, July 20, 1982: US04340585 (33 worldwide citation)

A non-toxic anionic resin selected from resins having a polymeric reticulated skeleton of styrenic or acrylic type, inert to the digestive enzymes, having a molecular weight higher than 1000 and containing ionizable amino groups, resins having a cellulosic reticulated skeleton modified by the introd ...


5
Rotini Leone Gabriele, Marchi Egidio: New pharmaceutical formulations with programmed release containing antiphlogistics.. Alfa Farmaceutici, February 3, 1988: EP0255002-A1 (28 worldwide citation)

New galenic formulations with programmed release, to be administered by oral route, containing as the active ingredient a compound endowed with antiphlogistic, analgesic and antipyretic activity like, for instance, an arylacetic or an arylpropionic acid and the pharmaceutically acceptable salts ther ...


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Egidio Marchi, Lauretta Montecchi: Process for the preparation of 3 iodo- and 3 bromorifamycin s. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, December 18, 1979: US04179438 (11 worldwide citation)

A process is disclosed for the preparation of 3 iodo-3 bromorifamycin S which consists in reacting rifamycin S with at least 2 equivalents of the corresponding halogen in the presence of at least one mole of pyridine for each equivalent of halogen. The reaction is carried out in inert, polar, hydrof ...


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Egidio Marchi, Lauretta Montecchi: Rifamycin derivatives and process for their preparation. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, April 29, 1980: US04200574 (10 worldwide citation)

8-amino and 8-iminorifamycins S and SV are prepared by reacting 8-methoxyrifamycin S with ammonia in an inert polar and hydrophillic solvent, converting the 8-iminorifamycin S into 8 aminorifamycin S by reaction with ammonium hydroxide in a mixture of chloroform and methanol and, if so desired, redu ...


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Manlio Cristofori, Valerio Borzatta, Mauro Morotti: Nicotinates of alkanediols having hypolipidaemic activity and pharmaceutical compositions containing them. Alfa Farmaceutici S p A, Bucknam and Archer, June 12, 1984: US04454145 (9 worldwide citation)

New compounds of general formula ##STR1## and salts therewith of pharmaceutically acceptable acids, wherein R and R.sub.1 independently represent a hydrogen atom or a straight or branched alkyl group having from 1 to 5 carbon atoms, and n is an integer from 4 to 12; and of general formula ##STR2## w ...


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Vincenzo Cannata, Graziano Zagnoni: Process for the optical resolution of mixtures of D- and L-2-(6-methoxy-2-naphthyl)-propionic acids. Alfa Farmaceutici S p A, Bucknam and Archer, August 16, 1983: US04399284 (5 worldwide citation)

A new process for the optical resolution of mixtures of d- and 1-2-(6-methoxy-2-naphthyl)-propionic acids, which comprises preparing a solution of a mixture of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids and an optically active organic base in a predetermined organic solvent, slowly cooling the ...


10
Valerio Borzatta: Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing pharmacological activity. Alfa Farmaceutici S p A, Stevens Davis Miller & Mosher, January 20, 1981: US04246201 (5 worldwide citation)

Compound of formula: ##STR1## wherein R represents hydrogen or an alkyl group having from 1 to 4 carbon atoms; R', R", R'" and R"", equal or different from each other represent hydrogen atoms or OH groups, with the limitation that when R', R", R'" and R"" are all hydrogen atoms R cannot be an hydrog ...