1
John F Krumme: Shape-memory surgical staple apparatus and method for use in surgical suturing. Alchemia, Howard L Rose, December 4, 1984: US04485816 (806 worldwide citation)

The staples are made of a material having the intrinsic property of shape memory, such that heating the material above a certain temperature known as the transition temperature causes any deformation introduced at temperatures below the transition temperature to be reversed, and the staple recovers ...


2
John F Krumme, Darel E Hodgson: Stapling device. Alchemia Partnership, Howard L Rose, November 5, 1985: US04550870 (251 worldwide citation)

A stapling device utilizes heat recoverable material (the driver) having shape memory to drive staples through materials to be joined and in one embodiment, against an anvil for crimping the ends of the staples. The heat recoverable material, preferably a metal such as Nitinol, may have heat applied ...


3
Meutermans Wim, Schafer Karl, West Michael Leo, Muldoon Craig, Foley Fiona, Bouloc Natalie, Tometzki Gerald: Compounds that interact with kinases. Alchemia, Meutermans Wim, Schafer Karl, West Michael Leo, Muldoon Craig, Foley Fiona, Bouloc Natalie, Tometzki Gerald, CULLEN Level 26 239 George Street Brisbane Queensland 4000, March 18, 2004: WO/2004/022572 (16 worldwide citation)

A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.


4
Thomas F Burke, Merwin F Hoover, John H Bradshaw: Multilayer metalized composite on polymer film product and process. Alchemia, Paul J Cook, March 28, 2000: US06042929 (13 worldwide citation)

A composite substrate material useful for fabricating printed circuits is provided comprising a polymeric film having at least one surface modified by plasma etching, a first thin metal nitride layer, a thin second metal nitride layer, and an electrically conductive third metal layer.


5
Istvan Toth, Gyula Dekany, Barry Kellam: Oligosaccharide synthesis. Alchemia, Williams Morgan and Amerson, June 3, 2003: US06573337 (11 worldwide citation)

The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention ...


6
Joachim Seifert, Latika Singh, Tracie E Ramsdale, Michael L West, Nicholas B Drinnan: Synthetic heparin pentasaccharides. Alchemia, Morrison & Foerster, June 2, 2009: US07541445 (10 worldwide citation)

Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.


7
Krumme John F, Hodgson Darel E: Controlled flow rate intravenous apparatus employing shape-memory flow-control element.. Alchemia, June 13, 1984: EP0110685-A1 (9 worldwide citation)

A unitary disposable conduit extends from the intravenous reservoir along a gravity-flow path to the patient, and incorporates a valve block containing an externally controlled flow-control valve. An electronic controller monitors the drop rate in a drop chamber which is an integral part of the disp ...


8
Istvan Toth, Gyula Dekany, Barry Kellam: Oligosaccharide synthesis. Alchemia, Williams Morgan and Amerson, April 20, 2004: US06723843 (8 worldwide citation)

The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention ...


9
Gyula Dekany, John Papagerogiou, Laurent Francois Bornaghi: Protecting groups for carbohydrate synthesis. Alchemia, Haynes and Boone, Mark D Moore, October 11, 2005: US06953850 (7 worldwide citation)

The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the specific deprotection of any subs ...


10
Brown Tracey: Composition visant a accroitre lefficacite de medicaments et methodes afferentes, A composition and method for the enhancement of the efficacy of drugs. Meditech Research, Alchemia Oncology, BORDEN LADNER GERVAIS, July 20, 2000: CA2370003 (6 worldwide citation)

The present invention relates to the enhancement of the efficacy of drugs, and more particularly, with overcoming the resistanceof cells or organisms to drugs. In particular, the present invention provides a method for enhancing the effectiveness of a cytotoxic oranti-neoplastic agent, comprising th ...