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Yuji Iwashita, Katsumi Ajisaka: Blood substitute containing modified hemoglobin. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, November 17, 1981: US04301144 (419 worldwide citation)

A novel modified hemoglobin was prepared. The hemoglobin is coupled with a polyalkylene glycol or its derivative, and the products are useful as a blood substitute. The oxygen-carrying capacity of this hemoglobin is nearly equal to that of a native hemoglobin, and the residence time in the circulati ...


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Katsumi Niki, Katsuyoshi Kobayashi, Hiroo Inoguchi, Tatsuhiko Yagi: Chemically modified electrodes and their uses. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, October 28, 1986: US04619754 (387 worldwide citation)

An electrically conducting solid electrode having a surface on which a nitrogen-containing electron mediator and a strong acidic cation exchange resin containing aromatic groups are immobilized is disclosed along with methods for producing this electrode and uses therefor.


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Yuji Iwashita, Katsumi Ajisaka, Keiji Iwasaki: Oxygen carrier. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, November 1, 1983: US04412989 (214 worldwide citation)

An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.


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Kounosuke Sano, Takayasu Tsuchida: Method for producing L-lysine by fermentation. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, August 24, 1982: US04346170 (49 worldwide citation)

An L-lysine producing microorganism which is obtained by incorporation into a host strain of the genus Escherichia of a hybrid plasmid having inserted therein a DNA fragment with genetic information controlling L-lysine production which is derived from a donor strain which is resistant to an L-lysin ...


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Ryota Yoshimoto, Nobukazu Kashima, Junji Hamuro, Koji Mitsugi: Immunoprophylactic and immunotherapeutic agents. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, December 6, 1988: US04789658 (39 worldwide citation)

An immunopropylactic and immunotherapeutic agent comprising human interleukin 2 of human cellular origin is disclosed along with a method of producing the agent.


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Takashi Tanaka, Eiji Ono, Koichi Takinami: Method of producing improved glyceride by lipase. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, June 23, 1981: US04275011 (24 worldwide citation)

A glyceride product is prepared by interesterifying a glyceride mixture in the presence of a lipase as a catalyst with a dihydric alcohol, a trihydric alcohol, or mixture thereof, said glyceride mixture being composed of at least two different glycerides or at least one glyceride and at least one fa ...


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Motohiko Hikuma, Tatsuru Kubo, Takeo Yasuda, Isao Karube, Shuichi Suzuki: Method for determining ammonia and sensor therefor. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, October 27, 1981: US04297173 (24 worldwide citation)

The concentration of ammonia in an aqueous liquid is determined by contacting a sample of the liquid with dissolved oxygen and with a microbial electrode comprising an oxygen-sensitive electrode, a porous membrane, and nitrifying bacteria confined or immobilised by the membrane which are in direct o ...


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Shinichi Inazuka, Shigekatsu Tsuchiya: Insect repellents and a method of repelling insects. Ajinomoto Company Incorporated, Oblon Fisher Spivak McClelland & Maier, August 26, 1980: US04219570 (23 worldwide citation)

A class of .alpha.-branched chain alkyl or alkenyl substituted benzene compounds have excellent repelling activities against numerous noxious insects.


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