1
Gail K Naughton, Jane Willoughby: Method for repairing cartilage. Advanced Tissue Sciences, Pennie & Edmonds, December 1, 1998: US05842477 (459 worldwide citation)

The present invention relates to methods of making and/or repairing cartilage in vivo comprising implanting into a patient, at a site of cartilage damage or loss, a biocompatible, non-living three-dimensional scaffold or framework structure in combination with periosteal/perichondrial tissue that ca ...


2
Gail K Naughton, Brian A Naughton: Three-dimensional cell and tissue culture system. Advanced Tissue Sciences, Pennie & Edmonds, August 22, 1995: US05443950 (191 worldwide citation)

The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance with the invention, cells derived from a desired tissue are inoculated and grown on a pre-established s ...


3
Anthony F Purchio, Michael Zimber, Noushin Dunkelman, Gail K Naughton, Brian A Naughton: Three-dimensional cartilage cultures. Advanced Tissue Sciences, Pennie & Edmonds, May 11, 1999: US05902741 (171 worldwide citation)

The present invention relates to a method of stimulating the proliferation and appropriate cell maturation of a variety of different cells and tissues in three-dimensional cultures in vitro using TGF-.beta. in the culture medium. In accordance with the invention, stromal cells, including, but not li ...


4
Sandra R Slivka, Lee Landeen: Three-dimensional stromal cell and tissue culture system. Advanced Tissue Sciences, Pennie & Edmonds, December 26, 1995: US05478739 (162 worldwide citation)

The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three-dimensional matrix while cycling the cultures between metabolically favorable and metabolically unfavorable (but noncytotoxic) conditions. The invention is based, at least in part, ...


5
Gail K Naughton, Jonathan N Mansbridge, R Emmett Pinney: Methods of making conditioned cell culture medium compositions. Advanced Tissue Sciences, Pennie & Edmonds, April 16, 2002: US06372494 (143 worldwide citation)

Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be condit ...


6
Gail K Naughton, Brian A Naughton: Three-dimensional culture of pancreatic parenchymal cells cultured living stromal tissue prepared in vitro. Advanced Tissue Sciences, Pennie & Edmonds, February 8, 2000: US06022743 (134 worldwide citation)

A stromal cell-based three-dimensional cell culture system is prepared which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal cells and connective tissue proteins naturally secreted by the stromal cells attach to and substantially en ...


7
Gail K Naughton, Brian A Naughton: Three-dimensional skin culture system. Advanced Tissue Sciences, Pennie & Edmonds, November 30, 1993: US05266480 (111 worldwide citation)

The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance with the invention, cells derived from a desired tissue are inoculated and grown on a pre-established s ...


8
Gail K Naughton, Brian A Naughton: Three-dimensional stromal tissue cultures. Advanced Tissue Sciences, Pennie & Edmonds, October 5, 1999: US05962325 (110 worldwide citation)

The present invention relates to a method of stimulating the proliferation and appropriate cell maturation of a variety of different cells and tissues in three-dimensional cultures in vitro using TGF-.beta. in the culture medium. In accordance with the invention, stromal cells, including, but not li ...


9
Dror Seliktar, Noushin Dunkelman, Alvin Edward Peterson, Ronda Elizabeth Schreiber, Jane Willoughby, Gail K Naughton: Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage. Advanced Tissue Sciences, Pennie & Edmunds, July 27, 1999: US05928945 (108 worldwide citation)

Mammalian cells capable of producing cartilage are cultured under a shear flow stress of about 1 to about 100 dynes/cm.sup.2 to produce artificial cartilage for surgical transplantation to replace damaged or missing cartilage. Shear flow stressed cells display enhanced maintenance of chondrocyte phe ...


10
Noushin Dunkelman, Alvin E Peterson, Lee Kevin Landeen, Joan Zeltinger: Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts. Advanced Tissue Sciences, Pennie & Edmonds, August 11, 1998: US05792603 (89 worldwide citation)

An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing vascular grafts is disclosed. Specifically, the present invention relates to an apparatus and method for seeding and culturing vascular grafts with human cells. The apparatus includes a fluid reservoir, a pum ...