1
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, June 13, 2000: US06075181 (548 worldwide citation)

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipula ...


2
Raju Kucherlapati, Aya Jakobovits: Method of making transgenic mice lacking endogenous heavy chains. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, August 17, 1999: US05939598 (541 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


3
Raju Kucherlapati, Aya Jakobovits, Daniel G Brenner, Daniel J Capon, Sue Klapholz: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, November 21, 2000: US06150584 (441 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...


4
Raju Kucherlapati, Aya Jakobovits, Sue Kalpholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, September 5, 2000: US06114598 (335 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


5
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of Xenogenetic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, December 19, 2000: US06162963 (291 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


6
Nobuaki Hori, Claude Geoffrey Davis, Krisztina M Zsebo, Aya Jakobovits: Production of a multimeric protein by cell fusion method. Abgenix, Japan Tobacco, Carol L Bozicevic Field & Francis Francis, June 29, 1999: US05916771 (247 worldwide citation)

The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produ ...


7
Aya Jakobovits, Xiao Dong Yang, Michael Gallo, Xiao Chi Jia: Human monoclonal antibodies to epidermal growth factor receptor. Abgenix, Christopher A Hare, May 22, 2001: US06235883 (175 worldwide citation)

In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences correspondin ...


8
Aya Jakobovits, Krisztina M Zsebo: Production of antibodies using Cre-mediated site-specific recombination. Abgenix, Japan Tobacco, Carol L Francis, Paula A Bozicevic Field & Francis Borden, October 10, 2000: US06130364 (171 worldwide citation)

A method to produce a cell expressing an antibody from a genomic sequence of the cell comprising a modified immunoglobulin locus using Cre-mediated site-specific recombination is disclosed. The method involves first transfecting an antibody-producing cell with a homology-targeting vector comprising ...


9
Aya Jakobovits, Krisztina M Zsebo: Production of antibodies using Cre-mediated site-specific recombination. Abgenix, Japan Tobacco, Carol L Francis, Paula A Bozicevic Field & Francis Borden, July 18, 2000: US06091001 (157 worldwide citation)

A method to produce a cell expressing an antibody from a genomic sequence of the cell comprising a modified immunoglobulin locus using Cre-mediated site-specific recombination is disclosed. The method involves first transfecting an antibody-producing cell with a homology-targeting vector comprising ...


10
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, January 6, 2004: US06673986 (131 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...