Kempf Dale J, Norbeck Daniel W, Erickson John W, Codacovi Lynn M, Sham Hing Leung, Plattner Jacob J: Retroviral protease inhibiting compounds.. Abbott Lab, December 19, 1990: EP0402646-A1 (243 worldwide citation)

A retroviral protease inhibiting compound of the formula A - X - B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (5) functionalized acyl, (6) fun ...

Backman Keith C, Carrino John J, Bond Sheila B, Laffler Thomas G: Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions.. Abbott Lab, Bioteknika International, July 31, 1991: EP0439182-A2 (202 worldwide citation)

The present invention involves methods of improving LCR and PCR amplification schemes by modifying at least one probe/primer end so that the probability of the probe/primer contributing to spurious signal development is greatly reduced. Only after specific hybridization of the modified probe/primer ...


Kempf Dale J, Plattner Jacob J, Norbeck Daniel W, Baker William R, Fung Anthony K L, Boyd Steven A, Erickson John W, Crowley Steven R: Retroviral protease inhibitors.. Abbott Lab, November 23, 1989: EP0342541-A2 (159 worldwide citation)

A retroviral protease inhibiting compound of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof.

Luly Jay Richard, Plattner John Jacob, Rosenberg Saul Howard, Fung Anthony K L: Peptidylaminodiols.. Abbott Lab, July 30, 1986: EP0189203-A2 (127 worldwide citation)

The invention relates to the renin inhibiting compounds of the formula: wherein R10 is A is hydrogen or an N-protecting group; w is 0 or 1; B is hydrogen, hydroxy, NH, N-alkyl, loweralkyl or arylalkyl; with the proviso that when w is 1, B is NH and when w is 0, B is hydrogen, hydroxy, loweralkyl or ...

Devereaux Sharon Murphy, Wilcox James L, Holzman Thomas Fredric, Gordon Julian, Ching Shanfun: Chromatographic binding assay devices and methods.. Abbott Lab, July 12, 1989: EP0323605-A2 (125 worldwide citation)

An assay device, method and kit for detecting or quantitating an analyte in a test sample containing or suspected of containing an analyte of interest. The analytical device comprises a chromatographic material containing a capture reagent, immobilized in a capture situs, and an application pad whic ...

Hayes Donald J, Wallace David B, Verlee Donald J, Houseman Kenneth R: Apparatus and process for reagent fluid dispensing and printing.. Abbott Lab, May 25, 1988: EP0268237-A2 (121 worldwide citation)

A system for printing and dispensing chemical reagents in precisely controlled volumes onto a medium at a precisely controlled location. A jetting tube (432), comprising an orifice (433) at one end and a fluid receiving aperture (431) at the other end, is concentrically mounted within a cylindrical ...

Kempf Dale J, Codacovi Lynn M, Norbeck Daniel W, Plattner Jacob J, Sham Hing L, Wittenberger Steven J, Zhao Chen: Retroviral protease inhibiting compounds.. Abbott Lab, May 27, 1992: EP0486948-A2 (116 worldwide citation)

A retroviral protease inhibiting compound of the formula A -X- B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhi ...

Luly Jay Richard, Kempf Dale John, Plattner Jacob John: Peptidylaminodiols.. Abbott Lab, July 22, 1987: EP0229667-A2 (111 worldwide citation)

A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, alpha , alpha - ...

Lyer Lokanathan M, Lyon Kenneth S, Yim Jeffrey B: Fiber-optic physiological probes.. Abbott Lab, January 31, 1990: EP0352610-A2 (105 worldwide citation)

Fiber-optic sensors suitable for monitoring physiological analyte concentration. An analyte-permeable matrix is disposed in the light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer, preferably methyl met ...