1
Kempf Dale J, Norbeck Daniel W, Erickson John W, Codacovi Lynn M, Sham Hing Leung, Plattner Jacob J: Retroviral protease inhibiting compounds.. Abbott Lab, December 19, 1990: EP0402646-A1 (243 worldwide citation)

A retroviral protease inhibiting compound of the formula A - X - B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (5) functionalized acyl, (6) fun ...


2
Backman Keith C, Carrino John J, Bond Sheila B, Laffler Thomas G: Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions.. Abbott Lab, Bioteknika International, July 31, 1991: EP0439182-A2 (202 worldwide citation)

The present invention involves methods of improving LCR and PCR amplification schemes by modifying at least one probe/primer end so that the probability of the probe/primer contributing to spurious signal development is greatly reduced. Only after specific hybridization of the modified probe/primer ...


3

4
Kempf Dale J, Plattner Jacob J, Norbeck Daniel W, Baker William R, Fung Anthony K L, Boyd Steven A, Erickson John W, Crowley Steven R: Retroviral protease inhibitors.. Abbott Lab, November 23, 1989: EP0342541-A2 (159 worldwide citation)

A retroviral protease inhibiting compound of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof.


5
Luly Jay Richard, Plattner John Jacob, Rosenberg Saul Howard, Fung Anthony K L: Peptidylaminodiols.. Abbott Lab, July 30, 1986: EP0189203-A2 (127 worldwide citation)

The invention relates to the renin inhibiting compounds of the formula: wherein R10 is A is hydrogen or an N-protecting group; w is 0 or 1; B is hydrogen, hydroxy, NH, N-alkyl, loweralkyl or arylalkyl; with the proviso that when w is 1, B is NH and when w is 0, B is hydrogen, hydroxy, loweralkyl or ...


6
Devereaux Sharon Murphy, Wilcox James L, Holzman Thomas Fredric, Gordon Julian, Ching Shanfun: Chromatographic binding assay devices and methods.. Abbott Lab, July 12, 1989: EP0323605-A2 (125 worldwide citation)

An assay device, method and kit for detecting or quantitating an analyte in a test sample containing or suspected of containing an analyte of interest. The analytical device comprises a chromatographic material containing a capture reagent, immobilized in a capture situs, and an application pad whic ...


7
Hayes Donald J, Wallace David B, Verlee Donald J, Houseman Kenneth R: Apparatus and process for reagent fluid dispensing and printing.. Abbott Lab, May 25, 1988: EP0268237-A2 (121 worldwide citation)

A system for printing and dispensing chemical reagents in precisely controlled volumes onto a medium at a precisely controlled location. A jetting tube (432), comprising an orifice (433) at one end and a fluid receiving aperture (431) at the other end, is concentrically mounted within a cylindrical ...


8
Kempf Dale J, Codacovi Lynn M, Norbeck Daniel W, Plattner Jacob J, Sham Hing L, Wittenberger Steven J, Zhao Chen: Retroviral protease inhibiting compounds.. Abbott Lab, May 27, 1992: EP0486948-A2 (116 worldwide citation)

A retroviral protease inhibiting compound of the formula A -X- B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhi ...


9
Luly Jay Richard, Kempf Dale John, Plattner Jacob John: Peptidylaminodiols.. Abbott Lab, July 22, 1987: EP0229667-A2 (111 worldwide citation)

A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, alpha , alpha - ...


10
Lyer Lokanathan M, Lyon Kenneth S, Yim Jeffrey B: Fiber-optic physiological probes.. Abbott Lab, January 31, 1990: EP0352610-A2 (105 worldwide citation)

Fiber-optic sensors suitable for monitoring physiological analyte concentration. An analyte-permeable matrix is disposed in the light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer, preferably methyl met ...