WO/2010/080605 is referenced by 37 patents.

A non-enzymatically self cleaving dipeptide element is provided that can be linked to known medicinal agents via an amide bond. The dipeptide will spontaneously be cleaved from the medicinal agent under physiological conditions through a reaction driven by chemical instability. Accordingly, the dipeptide element provides a means of linking various compounds to known medicinal agents wherein the compounds are subsequently released from the medicinal agent after a predetermined time of exposure to physiological conditions. For example, the dipeptide can be linked to an active site of a drug to form a prodrug and/or the dipeptide may comprise a depot polymer to sequester an injectable composition comprising the complex at the point of administration.

Title
Dipeptide linked medicinal agents
Application Number
PCT/US/2009/068711
Publication Number
2010/080605
Application Date
December 18, 2009
Publication Date
July 15, 2010
Inventor
Dimarchi Richard D
Agent
Breen John P
Assignee
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
IPC
A61K 38/28
A61K 38/00
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