This invention involves four novel peptides of the formulas I, II, III a IV isolated from natural sources and their synthetic analogs of general formula V and VI, where R1 represents acyl, alkyl or unprotected amino group, R2 represents amid, substituted amid, unprotected carboxylic group or ester, Xaa represents, independently from each other, proteinogenic amino acid, D-amino acid, non-standard amino acid or amino acid with the side chain modification, n means position of the amino acid replacement and m means the number of the replacements in the peptide chain, and their applications as antimicrobial, antiviral, antifungal, antiparasitic and anticancer compounds. Therefore, they are practical for the production of medication for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment. Formulas for summary: H-Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-NH2 (I) H-VaI-Asn-Trp-Lys-Lys-VaI-Leu-GIy-Lys-IIe-IIe-Lys-VaI-AIa-Lys-NH2 (II) H-VaI-Asn-Trp-Lys-Lys-IIe-Leu-GIy-Lys-IIe-IIe-Lys-VaI-AIa-Lys-NH2 (III) H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-NH2 (IV) R1-[Xaan]m -Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-R2 (V) R1-[Xaan]m-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-R2 (VI)

Title
Novel antimicrobial peptides and their application
Application Number
PCT/CZ2009/000034
Publication Number
2009/109156
Publication Date
September 11, 2009
Inventor
Turánek Jaroslav
Borovicková Lenka
Votruba Ivan
Bednárová Lucie
Fucík Vladimír
Voburka Zdenek
Cvacka Josef
Hovorka Oldrich
Slaninová Jirina
Cerovsky Václav
Agent
HERMAN Václav
Assignee
Turánek Jaroslav
Borovicková Lenka
Votruba Ivan
Bednárová Lucie
Fucík Vladimír
Voburka Zdenek
Cvacka Josef
Hovorka Oldrich
Slaninová Jirina
Cerovsky Václav
Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky Vvi
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